JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB61370

Anti-Factor VIII antibody

Be the first to review this product! Submit a review

|

(2 Publications)

Sheep Polyclonal Factor VIII antibody. Suitable for ELISA, Inhib and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human F8.

View Alternative Names

F8C, F8, Coagulation factor VIII, Antihemophilic factor, Procoagulant component, AHF

Key facts

Host species

Sheep

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ELISA, Inhib

applications

Immunogen

Recombinant Full Length Protein corresponding to Human F8.

P00451

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "Inhib" : {"fullname" : "Inhibition Assay", "shortname":"Inhib"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "Inhib-species-checked": "guaranteed", "Inhib-species-dilution-info": "", "Inhib-species-notes": "<p>Binds FVIII/vWF complex in plasma.</p>" } } }
style
left-column

You may be interested in:

AB108830

Factor VII Activity Assay Kit (Human, Colorimetric)

0

0 Reviews

View product

We recommend this product because it’s often used in the same experiment or related research.

We advise that you always check the datasheet to ensure it fits your experiments, or contact ourtechnical teamfor help.

style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Ion exchange chromatography
Purification notes
Salt fractionation followed by ion exchange chromatography.
Storage buffer
Constituents: 50% Glycerol (glycerin, glycerine), 50% Water
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Factor VIII also known as anti-hemophilic factor is a glycoprotein with a molecular mass of approximately 250 kDa. This protein circulates in the plasma mainly in the liver where hepatocytes produce it. Factor VIII remains inactive while circulating in the blood and exists within the factor VIII/von Willebrand factor complex. Upon activation it plays a significant role in the blood coagulation process.
Biological function summary

Factor VIII greatly contributes to hemostasis by serving as a cofactor for factor IXa forming the intrinsic tenase complex. This activation results in the conversion of factor X to factor Xa which is important for the common pathway of the coagulation cascade. By participating in the clotting process factor VIII ensures proper wound healing and prevention of blood loss.

Pathways

Factor VIII activity is pivotal within the coagulation cascade particularly the intrinsic and common pathways. Activation of the intrinsic pathway begins through interactions with factor IXa leading to efficient activation of factor X. This process closely relates factor VIII to proteins like factor IX and factor X ensuring proper clot formation and stabilization. Factor VIII products and assays are available to study and characterize its critical role in these pathways.

Factor VIII is closely associated with hemophilia A a genetic bleeding disorder resulting from deficiency or dysfunction of this protein. Patients with hemophilia A exhibit prolonged bleeding times due to impaired coagulation. The disorder links directly to von Willebrand factor as it protects factor VIII from degradation in circulation stabilizing its presence in the blood. Anti-factor VIII antibodies are important tools for diagnosing and studying factor VIII-related disorders.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Factor VIII, along with calcium and phospholipid, acts as a cofactor for F9/factor IXa when it converts F10/factor X to the activated form, factor Xa.
See full target information F8
style
left-column

Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Journal of thrombosis and haemostasis : JTH 18:306-317 PubMed31562694

2019

A mathematical model of coagulation under flow identifies factor V as a modifier of thrombin generation in hemophilia A.

Applications

Unspecified application

Species

Unspecified reactive species

Kathryn G Link,Michael T Stobb,Matthew G Sorrells,Maria Bortot,Katherine Ruegg,Marilyn J Manco-Johnson,Jorge A Di Paola,Suzanne S Sindi,Aaron L Fogelson,Karin Leiderman,Keith B Neeves

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 26:755-61 PubMed26192111

2015

Comparison of human coagulation factor VIII expression directed by cytomegalovirus and mammary gland-specific promoters in HC11 cells and transgenic mice.

Applications

ELISA

Species

Unspecified reactive species

Qing Wang,Siguo Hao,Liyuan Ma,Wenhao Zhang,Jiangbo Wan,Xiaohui Deng
View all publications
style
left-column
style
left-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
style
left-column
style
right-column

Associated Products

Select an associated product type
Alternative Product
Primary Antibodies

AB41188

Anti-Factor VIII antibody [27.4]

primary-antibodies

factor-viii-antibody-274-ab41188

0

(0 reviews)

Alternative Product
Primary Antibodies

AB78852

Anti-Factor VIII antibody [GMA-012]

primary-antibodies

factor-viii-antibody-gma-012-ab78852

0

(0 reviews)

Alternative Product
Primary Antibodies

AB171825

Anti-Factor VIII antibody

primary-antibodies

factor-viii-antibody-ab171825

0

(0 reviews)

Alternative Product
Primary Antibodies

AB203590

Anti-Factor VIII antibody

primary-antibodies

factor-viii-antibody-ab203590

0

(0 reviews)

Alternative Product
Primary Antibodies

AB236284

Anti-Factor VIII antibody

primary-antibodies

factor-viii-antibody-ab236284

0

(0 reviews)

style
bg-slate-100

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com