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AB124289

Anti-Factor Xa Heavy Chain antibody

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(1 Publication)

Sheep Polyclonal Factor X antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Native Full Length Protein corresponding to Human F10.

View Alternative Names

Coagulation factor X, Stuart factor, Stuart-Prower factor, F10

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Factor Xa Heavy Chain antibody (AB124289)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Factor Xa Heavy Chain antibody (AB124289)

ab124289, at 5 μg/ml, staining Factor Xa Heavy Chain in paraffin embedded Human vessels by Immunohistochemistry.

Key facts

Host species

Sheep

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Native Full Length Protein corresponding to Human F10.

P00742

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Precipitation Ammonium Sulphate
Storage buffer
pH: 7.2 Constituents: 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Factor Xa Heavy Chain sometimes referred to as 'anti Factor Xa' or 'anti FXa' plays a vital role in blood coagulation. This serine protease with a molecular mass around 43 kDa forms a critical part of the prothrombinase complex that converts prothrombin to thrombin. Factor Xa is widely expressed in the liver and circulates as an inactive zymogen in the bloodstream. Upon activation it becomes an important enzyme in the coagulation cascade driving the formation of a fibrin clot.
Biological function summary

The Factor Xa Heavy Chain is essential for the propagation of the clotting response. It exists as part of a larger complex where Factor Xa binds with Factor Va on activated platelets. This complex formation dramatically increases the conversion rate of prothrombin to active thrombin. Through this mechanism Factor Xa is indispensable for effective hemostasis ensuring stable chlot formation in response to vascular injury. Furthermore because of its pivotal role it is often a target for anticoagulant drugs which can inhibit its activity and reduce clot formation in the body.

Pathways

Factor Xa functions prominently in the coagulation cascade and the extrinsic pathway of blood coagulation. In these processes Factor Xa interacts importantly with Factor V to form the prothrombinase complex which accelerates the generation of thrombin. Thrombin then acts on fibrinogen resulting in fibrin clot formation. Additionally Factor Xa shares a pathway connection with tissue factor initiating the extrinsic pathway that rapidly advances the coagulation cascade following tissue injury.

Factor Xa has significant implications in thrombotic disorders like deep vein thrombosis and pulmonary embolism. An imbalance in its regulation can lead to excessive clot formation which poses serious health risks. Anticoagulants targeting Factor Xa help manage these conditions by blocking its activity and preventing thrombus progression. Additionally Factor Xa-related pathways involving proteins like Factor V play a role in hemophilia a disorder where coagulation is impaired highlighting the therapeutic importance of modulating Factor Xa activity in managing bleeding disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting (PubMed : 22409427). Factor Xa activates pro-inflammatory signaling pathways in a protease-activated receptor (PAR)-dependent manner (PubMed : 24041930, PubMed : 30568593, PubMed : 34831181, PubMed : 18202198). Up-regulates expression of protease-activated receptors (PARs) F2R, F2RL1 and F2RL2 in dermal microvascular endothelial cells (PubMed : 35738824). Triggers the production of pro-inflammatory cytokines, such as MCP-1/CCL2 and IL6, in cardiac fibroblasts and umbilical vein endothelial cells in PAR-1/F2R-dependent manner (PubMed : 30568593, PubMed : 34831181). Triggers the production of pro-inflammatory cytokines, such as MCP-1/CCL2, IL6, TNF-alpha/TNF, IL-1beta/IL1B, IL8/CXCL8 and IL18, in endothelial cells and atrial tissues (PubMed : 24041930, PubMed : 35738824, PubMed : 9780208). Induces expression of adhesion molecules, such as ICAM1, VCAM1 and SELE, in endothelial cells and atrial tissues (PubMed : 24041930, PubMed : 35738824, PubMed : 9780208). Increases expression of phosphorylated ERK1/2 in dermal microvascular endothelial cells and atrial tissues (PubMed : 24041930, PubMed : 35738824). Triggers activation of the transcription factor NF-kappa-B in dermal microvascular endothelial cells and atrial tissues (PubMed : 24041930, PubMed : 35738824). Activates pro-inflammatory and pro-fibrotic responses in dermal fibroblasts and enhances wound healing probably via PAR-2/F2RL1-dependent mechanism (PubMed : 18202198). Activates barrier protective signaling responses in endothelial cells in PAR-2/F2RL1-dependent manner; the activity depends on the cleavage of PAR-2/F2RL1 by factor Xa (PubMed : 22409427). Up-regulates expression of plasminogen activator inhibitor 1 (SERPINE1) in atrial tissues (PubMed : 24041930).
See full target information F10
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cancer management and research 12:7451-7463 PubMed32904436

2020

LncRNA DLX6-AS1 Promotes the Progression of Neuroblastoma by Activating STAT2 via Targeting miR-506-3p.

Applications

Unspecified application

Species

Unspecified reactive species

Yanping Hu,Huifang Sun,Jiting Hu,Xiaomin Zhang
View all publications
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