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AB232726

Anti-Factor XIa antibody

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Rabbit Polyclonal FXI antibody. Suitable for WB, IHC-P and reacts with Rat, Human samples.

View Alternative Names

Coagulation factor XI, FXI, Plasma thromboplastin antecedent, PTA, F11

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Factor XIa antibody (AB232726)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Factor XIa antibody (AB232726)

Formalin-fixed, paraffin-embedded rat liver tissue stained for Factor XIa using ab232726 at 20 μg/ml in immunohistochemical analysis. DAB staining.

Western blot - Anti-Factor XIa antibody (AB232726)
  • WB

Supplier Data

Western blot - Anti-Factor XIa antibody (AB232726)

All lanes:

Western blot - Anti-Factor XIa antibody (ab232726) at 2 µg/mL

All lanes:

HepG2 (human liver hepatocellular carcinoma cell line) cell lysate

Predicted band size: 70 kDa

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Western blot - Anti-Factor XIa antibody (AB232726)
  • WB

Supplier Data

Western blot - Anti-Factor XIa antibody (AB232726)

All lanes:

Western blot - Anti-Factor XIa antibody (ab232726) at 2 µg/mL

All lanes:

Recombinant rat Factor XIa protein

Predicted band size: 70 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat, Human

Applications

IHC-P, WB

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.20000-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.20000-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "<p></p>" } } }
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AB241037

Factor XIa Assay Kit

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We recommend this product because it’s often used in the same experiment or related research.

We advise that you always check the datasheet to ensure it fits your experiments, or contact ourtechnical teamfor help.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Purification notes
Antigen-specific affinity chromatography followed by Protein A affinity chromatography.
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: 55.77% Glycerol (glycerin, glycerine), 44.12% PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Factor XIa also known as Coagulation Factor XIa or FXIa plays an important role in the blood coagulation cascade. This serine protease has a molecular weight of approximately 160 kDa and derives from the zymogen Factor XI. Factor XIa is synthesized in the liver and circulates in the blood plasma. In its active form it cleaves the Arg369-Ile370 bond in Factor IX leading to the further activation of the coagulation pathway.
Biological function summary

Factor XIa is essential for hemostasis. It forms a part of the intrinsic pathway complex that contributes to the amplification of thrombin generation. This activity strengthens the formation of a stable fibrin clot which is critical to prevent excessive bleeding. Factor XIa is also involved in cellular response mechanisms beyond coagulation such as inflammatory processes.

Pathways

Factor XIa is a significant component of the intrinsic coagulation pathway and the contact activation system. It works closely with proteins like Factor IX and kallikrein facilitating the transformation of inactive proteins to their active states in a stepwise manner. These interactions support hemostatic balance and help maintain proper clot formation while preventing thrombosis.

Factor XIa has connections to thrombotic conditions such as deep vein thrombosis and ischemic stroke. Excessive activation of FXIa can contribute to pathological clot formation. Inhibitors like anti-XIa reduce activity and are explored for therapeutic interventions in these conditions. Additionally congenital Factor XI deficiency often called Hemophilia C presents a bleeding disorder that highlights FXIa's significance in coagulation.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.
See full target information F11
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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