Anti-Factor XIIIa antibody [F13A1/1448]
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(1 Review)
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(1 Publication)
Mouse Monoclonal Factor XIIIa antibody. Suitable for WB, Protein Array, IHC-P and reacts with Human, Recombinant full length protein - Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human F13A1 aa 1-200.
View Alternative Names
F13A, F13A1, Coagulation factor XIII A chain, Coagulation factor XIIIa, Protein-glutamine gamma-glutamyltransferase A chain, Transglutaminase A chain
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Factor XIIIa antibody [F13A1/1448] (AB218392)
Immunohistochemical analysis of formalin-fixed paraffin-embedded human histiocytoma tissue, labeling Factor XIIIa using ab218392 at 2 μg/mL.
- WB
Supplier Data
Western blot - Anti-Factor XIIIa antibody [F13A1/1448] (AB218392)
All lanes:
Western blot - Anti-Factor XIIIa antibody [F13A1/1448] (ab218392) at 1 µg/mL
Lane 1:
Recombinant Human Factor XIIIa protein
Lane 2:
HeLa cell lysate
Predicted band size: 83 kDa
false
- Protein Array
Unknown
Protein Array - Anti-Factor XIIIa antibody [F13A1/1448] (AB218392)
ab218392 was tested in protein array against over 19000 different full-length human proteins.
Z- and S- Score : The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target.
A MAb is specific to its intended target if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
Reactivity data
Properties and storage information
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Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Factor XIIIa is important for hemostasis facilitating the final stages of blood clot formation by cross-linking fibrin polymers. This enzyme does not function in isolation; it forms a tetrameric complex with two A subunits and two B subunits. The active form Factor XIIIa catalyzes the formation of covalent bonds between glutamine and lysine residues in fibrin chains. This enhances the mechanical strength and resistance of the clot preventing premature degradation.
Pathways
Factor XIIIa is part of the coagulation pathway specifically involved in the stabilization of fibrin in the final steps of the cascade. It interacts closely with proteins like fibrinogen and thrombin as these proteins are essential in the conversion of Factor XIII to Factor XIIIa and in clot formation. Factor XIIIa also plays a role in the wound healing process by stabilizing the ECM (extracellular matrix) through cross-linking fibrin fibronectin and collagen.
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Target data
Publications (1)
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iScience 27:110562 PubMed39175775
2024
Applications
Unspecified application
Species
Unspecified reactive species
Product promise
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