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AB122566

Anti-FAM107B antibody

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(3 Publications)

Rabbit Polyclonal FAM107B antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human FAM107B aa 100 to C-terminus.

View Alternative Names

C10orf45, FAM107B, Protein FAM107B

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FAM107B antibody (AB122566)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FAM107B antibody (AB122566)

ab122566, at 1/50 dilution, staining FAM107B in Paraffin Embedded Human stomach tissue by Immunohistochemistry.

Immunocytochemistry/ Immunofluorescence - Anti-FAM107B antibody (AB122566)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-FAM107B antibody (AB122566)

Immunofluorescent staining of Human cell line U-2 OS shows positivity in nucleus but not nucleoli. Recommended concentration of ab122566 1-4 µg/ml. Cells treated with PFA/Triton X-100.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human FAM107B aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9H098

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FAM107B also known as FLJ22026 or neuron navigator 3-like protein functions mechanically through interaction with other cellular proteins. This protein has an approximate molecular mass of 14 kilodaltons. It expresses mainly in neuronal tissues but also appears in other cell types at lower levels. Its pattern of expression suggests a role in cell-specific functions possibly linked to its mechanical properties.
Biological function summary

The protein FAM107B contributes to maintaining cellular processes in the nervous system. Although not part of a larger complex it seems to support cellular responses to stress and repair mechanisms. Its functions might involve regulation of cellular growth and development. The presence in neural tissues points to a potential role in neural differentiation or maintenance.

Pathways

FAM107B plays an important role within cellular stress response mechanisms particularly in neural tissues. It associates with pathways related to the MAPK signaling pathway impacting cellular responses to extracellular signals. Additionally it has interactions with proteins like MEK and ERK which are important in transmitting signals from receptors on the cell surface to DNA in the nucleus.

FAM107B has connections to neurological disorders and cancer. Aberrant expression patterns have been observed in certain types of brain tumors suggesting a link between FAM107B's expression levels and tumorigenesis. Alterations of this protein might also relate to neurodegenerative diseases where misregulation of its associated pathways could affect neuronal survival. Interactions with proteins like APC and b-catenin through these diseases add further significance to its functional importance.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information FAM107B
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 10:e2206792 PubMed36775874

2023

EHBP1L1 Drives Immune Evasion in Renal Cell Carcinoma through Binding and Stabilizing JAK1.

Applications

Unspecified application

Species

Unspecified reactive species

Yihui Pan,Guannan Shu,Liangmin Fu,Kangbo Huang,Xinwei Zhou,Chengpeng Gui,Huashan Liu,Xiaohan Jin,Minyu Chen,Pengju Li,Junjie Cen,Zihao Feng,Jun Lu,Zhenhua Chen,Jiaying Li,Quanhui Xu,Yinghan Wang,Hui Liang,Zhu Wang,Qiong Deng,Wei Chen,Junhang Luo,Jiefeng Yang,Jiaxing Zhang,Jinhuan Wei

Genomics, proteomics & bioinformatics 20:614-632 PubMed34763096

2021

A Global Multiregional Proteomic Map of the Human Cerebral Cortex.

Applications

Unspecified application

Species

Unspecified reactive species

Zhengguang Guo,Chen Shao,Yang Zhang,Wenying Qiu,Wenting Li,Weimin Zhu,Qian Yang,Yin Huang,Lili Pan,Yuepan Dong,Haidan Sun,Xiaoping Xiao,Wei Sun,Chao Ma,Liwei Zhang

The Journal of neuroscience : the official journal of the Society for Neuroscience 41:4910-4936 PubMed33888607

2021

SCA7 Mouse Cerebellar Pathology Reveals Preferential Downregulation of Key Purkinje Cell-Identity Genes and Shared Disease Signature with SCA1 and SCA2.

Applications

Unspecified application

Species

Unspecified reactive species

Anna Niewiadomska-Cimicka,Frédéric Doussau,Jean-Baptiste Perot,Michel J Roux,Celine Keime,Antoine Hache,Françoise Piguet,Ariana Novati,Chantal Weber,Binnaz Yalcin,Hamid Meziane,Marie-France Champy,Erwan Grandgirard,Alice Karam,Nadia Messaddeq,Aurélie Eisenmann,Emmanuel Brouillet,Hoa Huu Phuc Nguyen,Julien Flament,Philippe Isope,Yvon Trottier
View all publications
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Product promise

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