JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB106454

Anti-FAM120A/OSSA antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal FAM120A/OSSA antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human FAM120A.

View Alternative Names

C9orf10, KIAA0183, OSSA, FAM120A, Constitutive coactivator of PPAR-gamma-like protein 1, Oxidative stress-associated SRC activator, Protein FAM120A

1 Images
Western blot - Anti-FAM120A/OSSA antibody (AB106454)
  • WB

Unknown

Western blot - Anti-FAM120A/OSSA antibody (AB106454)

Lane 1:

Western blot - Anti-FAM120A/OSSA antibody (ab106454) at 0.5 µg/mL

Lane 2:

Western blot - Anti-FAM120A/OSSA antibody (ab106454) at 1 µg/mL

All lanes:

SK-N-SH cell lysate at 15 µg

Predicted band size: 101 kDa,11 kDa,121 kDa,122 kDa,15 kDa,22 kDa,24 kDa,25 kDa,26 kDa,32 kDa,33 kDa,34 kDa,35 kDa,36 kDa,38 kDa,39 kDa,43 kDa,44 kDa,45 kDa,46 kDa,47 kDa,58 kDa,61 kDa,63 kDa,66 kDa,67 kDa,78 kDa,79 kDa,90 kDa,92 kDa

Observed band size: 100 kDa,17 kDa,22 kDa,30 kDa,32 kDa,35 kDa,38 kDa,39 kDa,40 kDa,43 kDa,46 kDa,66 kDa,78 kDa,~28 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human FAM120A. The exact immunogen used to generate this antibody is proprietary information.

Q9NZB2

Specificity

ab106454 will not cross-react with FAM120B / PGCC1.

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-1 µg/mL", "WB-species-notes": "<p></p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
Up to 12 months
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FAM120A also known as OSSA is a protein that plays a role in cellular signaling. It has a mass of approximately 120 kDa. Researchers observe the expression of this protein in various tissues including testis ovary and brain. FAM120A functions as a scaffolding protein which means it helps organize other proteins at specific locations within cells to facilitate interactions and signaling pathways.
Biological function summary

FAM120A interacts with numerous cellular components and exhibits roles in regulating stress response. It integrates into the RNA granule complex allowing it to influence RNA stability and translation. Through its interaction with the cytoplasmic polyadenylation element-binding proteins it modulates mRNA processing offering insight into how cells manage protein production in response to environmental changes.

Pathways

FAM120A becomes integrated into signaling cascades like the PI3K/Akt pathway. It influences cell survival and growth by modulating interactions with proteins such as Src and Grb2. These interactions contribute to the regulation of key signaling activities that impact various cell functions including proliferation and apoptosis.

FAM120A has connections to cancer and cardiomyopathies. Alterations in its expression or function may affect disease pathogenesis. For instance its relationship with Src contributes to oncogenic signaling pathways influencing cancer progression. In cardiac diseases this protein interacts with pathways that involve binding partners like PI3K where its dysregulation can lead to aberrant heart function or pathology.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Component of the oxidative stress-induced survival signaling. May regulate the activation of SRC family protein kinases (PubMed : 19015244). May act as a scaffolding protein enabling SRC family protein kinases to phosphorylate and activate PI3-kinase (PubMed : 19015244). Binds IGF2 RNA and promotes the production of IGF2 protein (PubMed : 19015244).
See full target information FAM120A
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Protein & cell 10:104-119 PubMed29980933

2018

TMEM43-S358L mutation enhances NF-κB-TGFβ signal cascade in arrhythmogenic right ventricular dysplasia/cardiomyopathy.

Applications

Unspecified application

Species

Unspecified reactive species

Guoxing Zheng,Changying Jiang,Yulin Li,Dandan Yang,Youcai Ma,Bing Zhang,Xuan Li,Pei Zhang,Xiaoyu Hu,Xueqiang Zhao,Jie Du,Xin Lin
View all publications
style
left-column
style
left-column
style
right-column

Alternative Products

Primary Antibodies

AB156695

Anti-FAM120A/OSSA antibody

Immunoprecipitation - Anti-FAM120A/OSSA antibody (AB156695)

  • 0
  • 0
Primary Antibodies

AB229254

Anti-FAM120A/OSSA antibody

Immunocytochemistry/ Immunofluorescence - Anti-FAM120A/OSSA antibody (AB229254)

  • 0
  • 0

Complementary Products

Primary Antibodies

AB106455

Anti-FAM120B antibody

Western blot - Anti-FAM120B antibody (AB106455)

  • 0
  • 0
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB32072

Anti-c-Myc antibody [Y69] - ChIP Grade

BOND RX™ Validated|KO Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size|Advanced Validation

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-c-Myc antibody [Y69] - ChIP Grade (AB32072)

  • 4
  • 56
Primary Antibodies

AB17722

Anti-FMRP antibody

BOND RX™ Validated|KO Validated

Western blot - Anti-FMRP antibody (AB17722)

  • 4
  • 8

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com