JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB106455

Anti-FAM120B antibody

Be the first to review this product! Submit a review

|

(2 Publications)

Rabbit Polyclonal FAM120B antibody. Suitable for WB and reacts with Rat samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human FAM120B.

View Alternative Names

CCPG, KIAA1838, FAM120B, Constitutive coactivator of peroxisome proliferator-activated receptor gamma, Constitutive coactivator of PPAR-gamma, Constitutive coactivator of PPARG, PPARG constitutive coactivator 1, Protein FAM120B, PGCC1

1 Images
Western blot - Anti-FAM120B antibody (AB106455)
  • WB

Unknown

Western blot - Anti-FAM120B antibody (AB106455)

Lane 1:

Western blot - Anti-FAM120B antibody (ab106455) at 0.5 µg/mL

Lane 2:

Western blot - Anti-FAM120B antibody (ab106455) at 1 µg/mL

All lanes:

Rat thymus tissue lysate at 15 µg

Predicted band size: 103 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat

Applications

WB

applications

Immunogen

Synthetic Peptide within Human FAM120B. The exact immunogen used to generate this antibody is proprietary information.

Q96EK7

Specificity

ab106455 will not cross-react with FAM120A.

style
left-column

Complementary Products

Primary Antibodies

AB106454

Anti-FAM120A/OSSA antibody

Western blot - Anti-FAM120A/OSSA antibody (AB106454)

  • 0
  • 0
Primary Antibodies

AB72455

Anti-TR150 antibody

Immunoprecipitation - Anti-TR150 antibody (AB72455)

  • 0
  • 0
Primary Antibodies

AB203829

Anti-ZEB1 antibody [EPR17375]

20ul selling size|RabMAb|Recombinant|KO Validated

Flow Cytometry (Intracellular) - Anti-ZEB1 antibody [EPR17375] (AB203829)

  • 3
  • 3
Primary Antibodies

AB84876

Anti-FOG1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FOG1 antibody (AB84876)

  • 0
  • 0
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-1 µg/mL", "WB-species-notes": "<p></p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
Up to 12 months
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FAM120B also known as Constitutive Coactivator of Peroxisome Proliferator-Activated Receptor Gamma (CCPG) is a protein with a mass of approximately 96 kDa. It is commonly expressed in various tissues most notably in the brain liver and kidneys. Mechanistically FAM120B interacts with other signaling proteins and functions as a scaffold facilitating the assembly of various protein complexes. This role allows FAM120B to influence several downstream signaling cascades.
Biological function summary

The FAM120B protein significantly impacts cell survival and growth. It acts as part of a multiprotein complex contributing to the modulation of transcriptional regulation and cell cycle progression. FAM120B also plays a part in the cellular response to oxidative stress where it helps in managing antioxidants. This regulatory function positions FAM120B as an important element in maintaining cellular homeostasis and proper physiological function.

Pathways

FAM120B is involved in the PI3K/AKT pathway a critical signaling pathway that regulates cell survival and growth. FAM120B interacts with downstream proteins such as AKT1 facilitating signal transduction that drives cell proliferation and metabolism. Furthermore FAM120B participates in the PPAR signaling pathway linking it with other key regulatory proteins that mediate lipid metabolism and cellular differentiation.

FAM120B shows a connection to certain cancers such as liver cancer where its dysregulation may contribute to aberrant cell proliferation and tumor growth. This potential involvement associates FAM120B with proteins like AKT1 which also participates in oncogenic processes. Additionally FAM120B has been implicated in neurodegenerative diseases possibly through its role in oxidative stress response and interactions with related proteins that maintain neuronal health.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Functions as a transactivator of PPARG and ESR1. Functions in adipogenesis through PPARG activation (By similarity).
See full target information FAM120B
style
left-column

Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Biochimica et biophysica acta. Molecular basis of disease 1867:166237 PubMed34339838

2021

San1 deficiency leads to cardiomyopathy due to excessive R-loop-associated DNA damage and cardiomyocyte hypoplasia.

Applications

Unspecified application

Species

Unspecified reactive species

Zhiheng Liu,Xu Gao,Zhou Zhou,Sung Wook Kang,Yong Yang,Hao Liu,Chunqin Zhang,Zheng Wen,Xiaoquan Rao,Daowen Wang,Donnell White,Qinglin Yang,Qinqiang Long

Nature communications 9:2592 PubMed29968717

2018

A senataxin-associated exonuclease SAN1 is required for resistance to DNA interstrand cross-links.

Applications

Unspecified application

Species

Unspecified reactive species

Alex M Andrews,Heather J McCartney,Tim M Errington,Alan D D'Andrea,Ian G Macara
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com