JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB221578

Anti-FAM123B antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal FAM123B antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human AMER1 aa 500 to C-terminus.

View Alternative Names

FAM123B, WTX, AMER1, APC membrane recruitment protein 1, Amer1, Protein FAM123B, Wilms tumor gene on the X chromosome protein

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-FAM123B antibody (AB221578)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-FAM123B antibody (AB221578)

CACO-2 cells stained for FAM123B (green) using ab221578 (4 μg/ml) in ICC/IF.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human AMER1 aa 500 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q5JTC6

style
left-column

Complementary Products

Primary Antibodies

AB185924

Anti-Firefly Luciferase antibody [EPR17790]

RabMAb|Recombinant|20ul selling size

Immunocytochemistry/ Immunofluorescence - Anti-Firefly Luciferase antibody [EPR17790] (AB185924)

  • 4
  • 6
Primary Antibodies

AB185926

Anti-Renilla Luciferase antibody [EPR17792]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-Renilla Luciferase antibody [EPR17792] (AB185926)

  • 5
  • 1
Primary Antibodies

AB115521

Anti-FBXO9 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FBXO9 antibody (AB115521)

  • 0
  • 0
Primary Antibodies

AB122267

Anti-GPR112 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPR112 antibody (AB122267)

  • 0
  • 0
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" }, "Mouse": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FAM123B also known as AMER1 or WTX is a cytoplasmic protein with a mass of approximately 120 kDa. It is expressed in various tissues including the kidneys lungs and heart. The protein contains several domains that facilitate interactions with other proteins which aids in its role in multiple cellular processes. Due to its ability to bind other proteins FAM123B is largely involved in transcriptional regulation and signal transduction.
Biological function summary

The FAM123B protein influences the Wnt signaling pathway and modulates transcriptional activity in cells. It acts as a regulatory element in this pathway by interacting with beta-catenin playing a role in the degradation process. Through its association with beta-catenin FAM123B helps regulate gene expression that controls cell proliferation and differentiation. The ability of FAM123B to form complexes with other proteins enhances its functional diversity within cellular contexts.

Pathways

The modulation by FAM123B has significant implications within the Wnt signaling and beta-catenin degradation pathways. It interacts with other proteins within these pathways including APC and Axin which are important for maintaining cell stability and growth. The activity of FAM123B ensures proper signal transduction and transcriptional regulation emphasizing its importance in cellular communication and development.

Aberrations in FAM123B are linked to several pathological conditions such as Wilms tumor and colorectal cancer. Dysfunction in the Wnt signaling pathway where FAM123B plays a critical role leads to uncontrolled cell proliferation associated with these diseases. Associations with other proteins such as APC in colorectal cancer highlight the significance of FAM123B in cancer development. Understanding the interactions of FAM123B aids in unraveling the pathophysiology of these diseases.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context : acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development.
See full target information AMER1
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Translational oncology 26:101562 PubMed36228410

2022

ARNTL2 is an indicator of poor prognosis, promotes epithelial-to-mesenchymal transition and inhibits ferroptosis in lung adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Huan Zhang,Guangyao Shan,Xing Jin,Xiangyang Yu,GuoShu Bi,Mingxiang Feng,Hao Wang,Miao Lin,Cheng Zhan,Qun Wang,Ming Li
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com