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AB98144

Anti-FAM126A antibody

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(1 Publication)

Rabbit Polyclonal FAM126A antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human HYCC1 aa 150-450.

View Alternative Names

DRCTNNB1A, FAM126A, HYCC1, Hyccin, Down-regulated by CTNNB1 protein A

1 Images
Western blot - Anti-FAM126A antibody (AB98144)
  • WB

Unknown

Western blot - Anti-FAM126A antibody (AB98144)

7.5% SDS PAGE

All lanes:

Western blot - Anti-FAM126A antibody (ab98144) at 1/1000 dilution

All lanes:

Raji whole cell lysate at 30 µg

Predicted band size: 57 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human HYCC1 aa 150-450. The exact immunogen used to generate this antibody is proprietary information.

Q9BYI3

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FAM126A also known as Hyccin is a protein playing a mechanical role in cellular processes. It has a molecular mass of approximately 55 kDa and is mainly expressed in nervous tissue particularly the central nervous system. FAM126A shows high conservation among species indicating its importance in various physiological functions. Researchers identify key roles for this protein in regulating cell growth and maintaining proper cellular structure.
Biological function summary

FAM126A is involved in the functioning of cells through its integration in multiprotein complexes. It plays a role in the myelin production and maintenance which is important for normal nervous system function. The protein assembles into complexes that stabilize and promote the normal physiology of oligodendrocytes cells responsible for myelin formation. Dysfunction in this protein can disrupt these processes causing adverse effects on neural activity.

Pathways

FAM126A acts in the PI3K/Akt signaling pathway and processes related to myelination. Involvement in PI3K/Akt pathway links it to essential cellular mechanisms such as growth and survival. FAM126A shows interactions with proteins like Akt and mTOR which are significant in signal transduction related to cell survival and growth.

Abnormalities in FAM126A function have links to hypomyelination and congenital cataract-motor neuropathy. These conditions show connections to disrupted myelin formation and lead to neurological symptoms. Alterations in FAM126A are thought to affect myelination and interacts closely with proteins involved in myelination processes such as MAG impacting normal neural function and integrity.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed : 26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (PubMed : 26571211). HYCC1 plays a key role in oligodendrocytes formation, a cell type with expanded plasma membrane that requires generation of PtdIns(4)P (PubMed : 26571211). Its role in oligodendrocytes formation probably explains its importance in myelination of the central and peripheral nervous system (PubMed : 16951682, PubMed : 26571211). May also have a role in the beta-catenin/Lef signaling pathway (Probable).
See full target information HYCC1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Marine drugs 22: PubMed38921561

2024

Marine Cytotoxin Santacruzamate A Derivatives as Potent HDAC1-3 Inhibitors and Their Synergistic Anti-Leukemia Effects with Venetoclax.

Applications

Unspecified application

Species

Unspecified reactive species

Wanting Hao,Leyan Wang,Tongqiang Xu,Geng Jia,Yuqi Jiang,Chong Qin,Xiaoyang Li
View all publications
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Product promise

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