Rabbit Polyclonal FAM126A antibody. Suitable for WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human HYCC1 aa 150-450.
Images
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human HYCC1 aa 150-450. The exact immunogen used to generate this antibody is proprietary information. Database link Q9BYI3
Reactivity data
Select an application| WB | |
|---|---|
| Human | Tested |
| Mouse | Predicted |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info - | Notes - |
Target data
Function
Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (PubMed:26571211). HYCC1 plays a key role in oligodendrocytes formation, a cell type with expanded plasma membrane that requires generation of PtdIns(4)P (PubMed:26571211). Its role in oligodendrocytes formation probably explains its importance in myelination of the central and peripheral nervous system (PubMed:16951682, PubMed:26571211). May also have a role in the beta-catenin/Lef signaling pathway (Probable).
Alternative names
DRCTNNB1A, FAM126A, HYCC1, Hyccin, Down-regulated by CTNNB1 protein A
Recommended products
Rabbit Polyclonal FAM126A antibody. Suitable for WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human HYCC1 aa 150-450.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human HYCC1 aa 150-450. The exact immunogen used to generate this antibody is proprietary information. Database link Q9BYI3
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
FAM126A also known as Hyccin is a protein playing a mechanical role in cellular processes. It has a molecular mass of approximately 55 kDa and is mainly expressed in nervous tissue particularly the central nervous system. FAM126A shows high conservation among species indicating its importance in various physiological functions. Researchers identify key roles for this protein in regulating cell growth and maintaining proper cellular structure.
- Biological function summary
FAM126A is involved in the functioning of cells through its integration in multiprotein complexes. It plays a role in the myelin production and maintenance which is important for normal nervous system function. The protein assembles into complexes that stabilize and promote the normal physiology of oligodendrocytes cells responsible for myelin formation. Dysfunction in this protein can disrupt these processes causing adverse effects on neural activity.
- Pathways
FAM126A acts in the PI3K/Akt signaling pathway and processes related to myelination. Involvement in PI3K/Akt pathway links it to essential cellular mechanisms such as growth and survival. FAM126A shows interactions with proteins like Akt and mTOR which are significant in signal transduction related to cell survival and growth.
- Associated diseases and disorders
Abnormalities in FAM126A function have links to hypomyelination and congenital cataract-motor neuropathy. These conditions show connections to disrupted myelin formation and lead to neurological symptoms. Alterations in FAM126A are thought to affect myelination and interacts closely with proteins involved in myelination processes such as MAG impacting normal neural function and integrity.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Western blot - Anti-FAM126A antibody (ab98144)
7.5% SDS PAGE
All lanes: Western blot - Anti-FAM126A antibody (ab98144) at 1/1000 dilution
All lanes: Raji whole cell lysate at 30 µg
Predicted band size: 57 kDa
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