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AB224116

Anti-FAM129B antibody

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(1 Publication)

Rabbit Polyclonal FAM129B antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human NIBAN2 aa 200-350.

View Alternative Names

C9orf88, FAM129B, NIBAN2, Protein Niban 2, Meg-3, Melanoma invasion by ERK, Niban-like protein 1, Protein FAM129B, MINERVA

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FAM129B antibody (AB224116)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FAM129B antibody (AB224116)

Paraffin-embedded human placenta tissue stained for FAM129B with ab224116 (1/2500) in immunohistochemical analysis.

Western blot - Anti-FAM129B antibody (AB224116)
  • WB

Supplier Data

Western blot - Anti-FAM129B antibody (AB224116)

All lanes:

Western blot - Anti-FAM129B antibody (ab224116) at 1/100 dilution

Lane 1:

RT4 (human urinary bladder cancer cell line) cell lysate

Lane 2:

U-251 MG sp (human brain glioma cell line) cell lysate

Lane 3:

Human plasma (IgG/HSA depleted)

Lane 4:

Human liver tissue lysate

Lane 5:

Human tonsil tissue lysate

Predicted band size: 83 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human NIBAN2 aa 200-350. The exact immunogen used to generate this antibody is proprietary information.

Q96TA1

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/2500 - 1/5000", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FAM129B also known as NIBAN2 functions as a protein implicated in cell survival signaling. It weighs approximately 75 kDa. Expression of FAM129B is detected in various tissues with prominence in the lymphoid tissues and central nervous system. Researchers have highlighted its role in apoptosis regulation where it interacts with other molecules to affect cell fate decisions under stress conditions.
Biological function summary

FAM129B engages in apoptosis modulation and cell survival playing a significant part in cellular stress response. The protein often partners with other components to form complexes that influence intracellular signaling pathways. Specifically by interacting with protein tyrosine phosphatases it affects the delicate balance between survival and programmed cell death providing cells the ability to adapt to fluctuating environmental challenges.

Pathways

FAM129B integrates into the MAPK and PI3K/AKT signaling pathways which are vital for regulating cell survival proliferation and differentiation. Within these pathways FAM129B associates with proteins like AKT and ERK that mediate its impact on cell survival signaling. Its involvement in these pathways suggests a regulatory role in cellular responses to external stimuli contributing to the maintenance of homeostasis.

Abnormal expression or dysfunction of FAM129B links to the pathophysiology of cancers and neurodegenerative diseases. For instance in cancer its interaction with AKT has been implicated in enhancing cell survival potentially leading to tumorigenesis. Additionally the altered regulation of FAM129B has connections to Alzheimer's disease where it may interact with other proteins like tau contributing to neurodegenerative processes.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro.
See full target information NIBAN2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in cell and developmental biology 11:1240039 PubMed37691832

2023

Inceptor facilitates acrosomal vesicle formation in spermatids and is required for male fertility.

Applications

Unspecified application

Species

Unspecified reactive species

Sara Bilekova,Balma Garcia-Colomer,Alberto Cebrian-Serrano,Silvia Schirge,Karsten Krey,Michael Sterr,Thomas Kurth,Stefanie M Hauck,Heiko Lickert
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

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