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AB75638

Anti-FAM129B antibody

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(1 Publication)

Rabbit Polyclonal FAM129B antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human NIBAN2.

View Alternative Names

C9orf88, FAM129B, NIBAN2, Protein Niban 2, Meg-3, Melanoma invasion by ERK, Niban-like protein 1, Protein FAM129B, MINERVA

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-FAM129B antibody (AB75638)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-FAM129B antibody (AB75638)

ab75638 at 1/100 dilution staining FAM129B in human Hela cells by ICC/IF.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Synthetic Peptide within Human NIBAN2. The exact immunogen used to generate this antibody is proprietary information.

Q96TA1

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/200", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab75638 was purified using an epitope-specific immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Stable for 12 months at -20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FAM129B also known as NIBAN2 functions as a protein implicated in cell survival signaling. It weighs approximately 75 kDa. Expression of FAM129B is detected in various tissues with prominence in the lymphoid tissues and central nervous system. Researchers have highlighted its role in apoptosis regulation where it interacts with other molecules to affect cell fate decisions under stress conditions.
Biological function summary

FAM129B engages in apoptosis modulation and cell survival playing a significant part in cellular stress response. The protein often partners with other components to form complexes that influence intracellular signaling pathways. Specifically by interacting with protein tyrosine phosphatases it affects the delicate balance between survival and programmed cell death providing cells the ability to adapt to fluctuating environmental challenges.

Pathways

FAM129B integrates into the MAPK and PI3K/AKT signaling pathways which are vital for regulating cell survival proliferation and differentiation. Within these pathways FAM129B associates with proteins like AKT and ERK that mediate its impact on cell survival signaling. Its involvement in these pathways suggests a regulatory role in cellular responses to external stimuli contributing to the maintenance of homeostasis.

Abnormal expression or dysfunction of FAM129B links to the pathophysiology of cancers and neurodegenerative diseases. For instance in cancer its interaction with AKT has been implicated in enhancing cell survival potentially leading to tumorigenesis. Additionally the altered regulation of FAM129B has connections to Alzheimer's disease where it may interact with other proteins like tau contributing to neurodegenerative processes.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro.
See full target information NIBAN2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

American journal of reproductive immunology (New York, N.Y. : 1989) 93:e70054 PubMed39918432

2025

The Effect of Acupoint Sticking Therapy on Serum Estrogen Levels and Endometrial Polyp Tissue Receptor Expression in Postmenopausal Patients With Endometrial Polyps.

Applications

Unspecified application

Species

Unspecified reactive species

Da Zhang,Ying Chen,Liangyu Zhang,Yang Wang
View all publications
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Product promise

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