Anti-FAM134C antibody [EPR11765]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

FAM134C also known as family with sequence similarity 134 member C is a protein involved in autophagy processes. It has a molecular mass of approximately 54 kDa. This protein localizes mainly within the endoplasmic reticulum (ER) membrane and it is expressed in several tissues including the brain and liver. FAM134C plays an essential role in regulating the ER shape and maintaining cellular homeostasis.

Biological function summary

The protein participates in the process of selective autophagy particularly ER-phagy which is the degradation of ER fragments. This function indicates that it is part of a broader complex that regulates the destruction of damaged or excessive organelles which is important for neuron and liver cell function. FAM134C interacts with LC3 proteins during these processes acting as a receptor that identifies ER regions targeted for degradation.

Pathways

Researchers recognize FAM134C's involvement in the cellular pathway of autophagy and apoptosis. The protein operates within these pathways by interacting with other autophagy-related proteins such as ATG8 family members which aid in forming autophagosomes. These pathways influence the balance between cell survival and cell death showcasing the protein's role in maintaining cellular health and function.

Associated diseases and disorders

Studies indicate a connection of FAM134C to neurodegenerative diseases and cancer. Dysregulation of its function can lead to the accumulation of damaged organelles contributing to neurodegenerative conditions like Alzheimer's disease. Moreover aberrant expression levels of FAM134C have been noted in certain cancer types suggesting its involvement in cancer progression. Disorders involving this protein often also implicate the LC3 protein reinforcing its participation in pathways related to pathological conditions.