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AB122440

Anti-FAM13A antibody

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(4 Publications)

Rabbit Polyclonal FAM13A antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human FAM13A aa 900 to C-terminus.

View Alternative Names

FAM13A1, KIAA0914, FAM13A, Protein FAM13A

5 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FAM13A antibody (AB122440)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FAM13A antibody (AB122440)

Immunohistochemical analysis of human small intestine labeling FAM13A with ab122440 showing strong cytoplasmic positivity in glandular cells.

Immunocytochemistry/ Immunofluorescence - Anti-FAM13A antibody (AB122440)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-FAM13A antibody (AB122440)

Immunocytochemistry/ Immunofluorescence analysis of U2-OS cells labeling FAM13A with ab122440 showing localization to nucleoli, cytosol & cell junctions.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FAM13A antibody (AB122440)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FAM13A antibody (AB122440)

Immunohistochemical analysis of human cerebral cortex labeling FAM13A with ab122440 showing strong cytoplasmic positivity in neurons.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FAM13A antibody (AB122440)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FAM13A antibody (AB122440)

Immunohistochemical analysis of human fallopian tube labeling FAM13A with ab122440 showing strong cytoplasmic positivity in glandular cells.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FAM13A antibody (AB122440)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FAM13A antibody (AB122440)

Immunohistochemical analysis of human testis labeling FAM13A with ab122440 showing strong cytoplasmic positivity in glandular cells in seminiferous duct.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human FAM13A aa 900 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

O94988

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500 - 1/1000", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The FAM13A protein also known as Family with Sequence Similarity 13 Member A has a mass of approximately 120 kDa. It plays a role in cellular signaling and mechanisms related to cytoskeletal dynamics. FAM13A is expressed in various tissues with high levels present in the lungs and to some extent in skeletal muscle and adrenal glands. The expression pattern indicates its broad functional roles influencing multiple physiological processes.
Biological function summary

FAM13A contributes to the regulation of cell migration and adhesion. It interacts with the actin cytoskeleton and influences cellular morphology and movement. FAM13A is known to be part of a complex involved in Rho GTPase signaling which regulates actin dynamics and influences cell shape and movement. This involvement highlights its significant role in cellular communication and structural organization.

Pathways

FAM13A has a connection to the Wnt signaling and Rho GTPase pathways. These pathways are key in cellular differentiation and cytoskeletal rearrangements. FAM13A interacts with proteins like DVL1 within the Wnt pathway and RhoA in the Rho GTPase signaling pathway. Its role in these pathways suggests its involvement in transducing signals that affect cell fate and structure.

FAM13A has associations with chronic obstructive pulmonary disease (COPD) and lung cancer. In COPD altered FAM13A expression affects lung function possibly through its role in cytoskeletal regulation and cell migration. It has been linked with proteins involved in inflammation and cell adhesion. In the context of lung cancer aberrant FAM13A expression might contribute to tumor progression by influencing pathways related to cell movement and invasion. Understanding its interactions and functions in these conditions could lead to new insights in disease treatment and prevention.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information FAM13A
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

American journal of respiratory cell and molecular biology 68:577-590 PubMed36749583

2023

AKT Phosphorylates FAM13A and Promotes Its Degradation via CUL4A/DDB1/DCAF1 E3 Complex.

Applications

Unspecified application

Species

Unspecified reactive species

Lu Gong,Samuel Bates,Yujun Li,Xin Lin,Wenyi Wei,Xiaobo Zhou

International journal of molecular sciences 22: PubMed33919074

2021

Hypoxia-Induced Regulates the Proliferation and Metastasis of Non-Small Cell Lung Cancer Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Iwona Ziółkowska-Suchanek,Marta Podralska,Magdalena Żurawek,Joanna Łaczmańska,Katarzyna Iżykowska,Agnieszka Dzikiewicz-Krawczyk,Natalia Rozwadowska

Experimental & molecular medicine 51:1-16 PubMed31164635

2019

microRNA-328 in exosomes derived from M2 macrophages exerts a promotive effect on the progression of pulmonary fibrosis via FAM13A in a rat model.

Applications

Unspecified application

Species

Unspecified reactive species

Meng-Ying Yao,Wei-Hong Zhang,Wen-Tao Ma,Qiu-Hong Liu,Li-Hua Xing,Gao-Feng Zhao

Journal of Cancer 8:3933-3938 PubMed29187867

2017

as a Novel Hypoxia-Induced Gene in Non-Small Cell Lung Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Iwona Ziółkowska-Suchanek,Maria Mosor,Marta Podralska,Katarzyna Iżykowska,Piotr Gabryel,Wojciech Dyszkiewicz,Ryszard Słomski,Jerzy Nowak
View all publications
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Product promise

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