JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB121364

Anti-FAM172A antibody

Be the first to review this product! Submit a review

|

(8 Publications)

Rabbit Polyclonal FAM172A antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 8 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ARB2A aa 1-150.

View Alternative Names

C5orf21, FAM172A, ARB2A, Cotranscriptional regulator ARB2A, ARB2 cotranscriptional regulator A, Cotranscriptional regulator FAM172A, Protein FAM172A

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-FAM172A antibody (AB121364)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-FAM172A antibody (AB121364)

Immunocytochemistry analysis of U-251 MG (human brain glioma cell line) cells labelling FAM172A with ab121364 at 2 μg/mL.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human ARB2A aa 1-150. The exact immunogen used to generate this antibody is proprietary information.

Q8WUF8

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25000-2.00000 µg/mL", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
style
left-column
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FAM172A also known as KIAA1690 is a protein that plays a significant role in the human body. It has an approximate molecular mass of 72 kDa. Researchers find FAM172A expression in various tissues indicating active participation in multiple cellular processes. Due to its widespread presence it attracts much interest in functional studies although specific details about its biochemical activity remain under investigation.
Biological function summary

The protein encoded by FAM172A participates in the cellular maintenance processes. While not conclusively part of any known complex its interactions suggest a regulatory role potentially in nucleic acid binding or cellular signaling processes. Studies also show its presence at the transcriptional level in cells indicating an influence on gene expression.

Pathways

FAM172A potentially connects to important cellular signaling pathways including the PI3K-Akt pathway. This pathway is important for cell survival and proliferation. Additionally FAM172A shows interaction tendencies with proteins like Akt1 reinforcing its participation in signaling networks that maintain cellular health and function.

FAM172A has associations with conditions like cancer. Its role in cellular growth pathways suggests that mutations or dysregulation of FAM172A might contribute to oncogenesis. Connections to proteins involved in cancer-related pathways including mTOR indicate potential targets for therapeutic intervention. Researchers continue to investigate how alterations in FAM172A expression or function contribute to disease states aiming for new treatment strategies.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Plays a role in the regulation of alternative splicing, by interacting with AGO2 and CHD7. Seems to be required for stabilizing protein-protein interactions at the chromatin-spliceosome interface. May have hydrolase activity.
See full target information ARB2A
style
left-column

Publications (8)

Recent publications for all applications. Explore the full list and refine your search

Life science alliance 6: PubMed37221016

2023

The CHARGE syndrome-associated protein FAM172A controls AGO2 nuclear import.

Applications

Unspecified application

Species

Unspecified reactive species

Sephora Sallis,Félix-Antoine Bérubé-Simard,Benoit Grondin,Elizabeth Leduc,Fatiha Azouz,Catherine Bélanger,Nicolas Pilon

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 36:e22176 PubMed35129866

2022

CHARGE syndrome-associated proteins FAM172A and CHD7 influence male sex determination and differentiation through transcriptional and alternative splicing mechanisms.

Applications

Unspecified application

Species

Unspecified reactive species

Catherine Bélanger,Tatiana Cardinal,Elizabeth Leduc,Robert S Viger,Nicolas Pilon

Digestive diseases and sciences : PubMed32945983

2020

FAM172A Deletion May Enhance Hepatic Steatosis by Promoting ER Stress.

Applications

Unspecified application

Species

Unspecified reactive species

Fan Xiao,Meixin Gao,Junru Yang,Lingling He,Hongshan Wei

Translational cancer research 9:5637-5644 PubMed35117927

2020

FAM172A affects cell proliferation and apoptosis not by targeting β-tubulin in HepG2 cells.

Applications

Unspecified application

Species

Unspecified reactive species

Ai-Min Xu,Chuan-Jiang He,Zureguli Tuerxun,Abuduaini Anikezi

Biology open 9: PubMed31988090

2020

FAM172A inhibits EMT in pancreatic cancer via ERK-MAPK signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Ying Chen,Peihui Liu,Di Shen,Han Liu,Lepeng Xu,Jian Wang,Daguang Shen,He Sun,Hongkui Wu

Oncology letters 14:3587-3593 PubMed28927116

2017

Expression of family with sequence similarity 172 member A and nucleotide-binding protein 1 is associated with the poor prognosis of colorectal carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Wenjun Liu,Shuang Wang,Kai Qian,Jinqian Zhang,Zhi Zhang,Hao Liu

Oncology reports 37:3554-3564 PubMed28440497

2017

miR‑27a promotes proliferation, migration, and invasion of colorectal cancer by targeting FAM172A and acts as a diagnostic and prognostic biomarker.

Applications

Unspecified application

Species

Unspecified reactive species

Wenjun Liu,Kai Qian,Xing Wei,Haijun Deng,Bei Zhao,Qing Chen,Jinqian Zhang,Hao Liu

Molecular medicine reports 13:353-8 PubMed26573560

2015

FAM172A protein promotes the proliferation of human papillary thyroid carcinoma cells via the p38 mitogen-activated protein kinase pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Mei-Fang Li,Rong Zhang,Ming-Gao Guo,Lian-Xi Li,Han-Kui Lu,Jun-Xi Lu,Wei-Ping Jia
View all publications
style
left-column
style
left-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
style
left-column
style
right-column
style
bg-slate-100

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com