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AB126340

Anti-FAM173A antibody

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(1 Publication)

Rabbit Polyclonal FAM173A antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ANTKMT aa 100 to C-terminus.
2 Images
Immunocytochemistry/ Immunofluorescence - Anti-FAM173A antibody (AB126340)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-FAM173A antibody (AB126340)

Immunofluorescent staining of Human cell line U-2 OS shows positivity in cytoplasm. Recommended concentration of ab126340 1-4 µg/ml. Cells treated with PFA/Triton X-100.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FAM173A antibody (AB126340)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FAM173A antibody (AB126340)

ab126340, at 1/20 dilution, staining FAM173A in Paraffin-embedded Human cerebral cortex tissue by Immunohistochemistry.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human ANTKMT aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9BQD7

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/50", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FAM173A also known as Family with Sequence Similarity 173 Member A is a protein with a mass of approximately 33 kDa. It works mechanically within the cell and is thought to have a role in mitochondrial dynamics possibly influencing mitochondrial partitioning. FAM173A is widely expressed in various tissues but high expression levels have been reported in the brain and muscle tissues. Its subcellular localization suggests a mitochondrial association which might indicate specific functions linked to energy production or regulation within the mitochondria.
Biological function summary

The precise role of FAM173A is still not entirely understood yet it appears to participate in mitochondrial maintenance and possibly cellular energy homeostasis. FAM173A might function as part of larger protein complexes potentially impacting the regulation of mitochondrial genome integrity or biogenesis. Its involvement in these processes highlights the importance of FAM173A in maintaining cellular functions and energy balance contributing to the proper physiological functions of tissues with high metabolic demands.

Pathways

FAM173A operates within mitochondrial-related pathways that are critical for energy metabolism and maintaining cellular homeostasis. It might interact with components of the oxidative phosphorylation pathway though specific pathway associations require further elucidation. FAM173A possibly intersects with proteins like MFN2 and OPA1 which are known to regulate mitochondrial fusion and fission processes. Understanding how these interactions affect cellular energy balance and mitochondrial morphology is essential for full comprehension of FAM173A's role within these pathways.

Research indicates that abnormal FAM173A function might be linked to neurodegenerative diseases and muscular disorders. Altered expression or mutations in FAM173A have been studied in diseases such as Alzheimer's and muscular dystrophies. FAM173A's connection to these diseases may involve interactions with proteins like APP in Alzheimer's disease and dystrophin in muscular disorders. These associations highlight the potential of FAM173A as a target for therapeutic strategies aiming to mitigate the effects of these conditions by restoring proper mitochondrial function.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Mitochondrial protein-lysine N-methyltransferase that trimethylates adenine nucleotide translocases ANT2/SLC25A5 and ANT3/SLC25A6, thereby regulating mitochondrial respiration (PubMed : 31213526). Probably also trimethylates ANT1/SLC25A4 (PubMed : 31213526).
See full target information ANTKMT

Alternative Names

C16orf24, FAM173A, RJD7, ANTKMT, Adenine nucleotide translocase lysine N-methyltransferase, ANT-KMT
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Publications (1)

Recent publications for all applications. Explore the full listand refine your search

Scientific reports 6:38192 PubMed27917907

2016

ECAT1 is essential for human oocyte maturation and pre-implantation development of the resulting embryos.

Applications

Unspecified application

Species

Unspecified reactive species

Changyu Liu,Min Li,Tianjie Li,Hongcui Zhao,Jin Huang,Yun Wang,Qian Gao,Yang Yu,Qinghua Shi
View all publications
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Product promise

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