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AB121828

Anti-FAM83H antibody

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(1 Publication)

Rabbit Polyclonal FAM83H antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human FAM83H aa 750-900.

View Alternative Names

Protein FAM83H, FAM83H

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FAM83H antibody (AB121828)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FAM83H antibody (AB121828)

Immunohistochemical staining of Human vagina shows strong cytoplasmic and nuclear positivity in squamous epithelial cells using ab121828

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FAM83H antibody (AB121828)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FAM83H antibody (AB121828)

ab121828, at a 1/200 dilution, staining FAM83H in paraffin embedded Human vagina tissue by Immunohistochemistry.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human FAM83H aa 750-900. The exact immunogen used to generate this antibody is proprietary information.

Q6ZRV2

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Alternative Products

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Primary Antibodies

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RabMAb|Recombinant

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Primary Antibodies

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Anti-EXD2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EXD2 antibody (AB121236)

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Primary Antibodies

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HENMT1 antibody (AB121991)

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Primary Antibodies

AB121960

Anti-HINT3 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HINT3 antibody (AB121960)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FAM83H also known as Family with Sequence Similarity 83 Member H is a protein with a mass of approximately 127 kDa. This protein is found mainly in dental tissues including ameloblasts where it plays a role in enamel formation. Its expression can also be detected in other tissues indicating its importance beyond enamel mineralization. FAM83H-localized at the cell membrane involves interactions with other proteins contributing to cellular processes.
Biological function summary

FAM83H acts as an important player in the mineralization of enamel. It may not seem like it but during enamel development FAM83H ensures proper structural integrity and stability of the enamel matrix. FAM83H is not a part of any complex but associates with other proteins such as casein kinase 1 which phosphorylates it regulating its activity in the amelogenesis process. By maintaining normal enamel development FAM83H aids in dental health and disease prevention.

Pathways

FAM83H functions in processes related to enamel formation and dental tissue development. This protein associates with the Wnt signaling pathway important for regulating cell proliferation and differentiation in various tissues. FAM83H interacts with proteins like Axin an important component of the Wnt pathway modulating cell signaling for proper tooth development. Wnt pathway's influence is detectable in many biological processes confirming FAM83H's role in maintaining essential signaling networks within cells.

FAM83H mutations link to amelogenesis imperfecta a disorder characterized by defective enamel formation. This condition can lead to issues such as abnormal tooth appearance and increased susceptibility to dental caries. FAM83H mutations alter gene functionality impacting its interaction with proteins like casein kinase 1. Another disease associated with FAM83H is Ehlers-Danlos syndrome though this connection is less direct but noteworthy involving extracellular matrix proteins. Understanding FAM83H’s involvement in these disorders aids in the development of diagnostic and therapeutic strategies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May play a major role in the structural organization and calcification of developing enamel (PubMed : 18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed : 23902688).
See full target information FAM83H
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

American journal of physiology. Renal physiology 313:F973-F983 PubMed28724612

2017

Regulation of PDZ domain-containing 1 (PDZK1) expression by hepatocyte nuclear factor-1α (HNF1α) in human kidney.

Applications

Unspecified application

Species

Unspecified reactive species

Katharina Prestin,Janine Hussner,Celio Ferreira,Isabell Seibert,Vivien Breitung,Uwe Zimmermann,Henriette E Meyer Zu Schwabedissen
View all publications
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Product promise

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