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AB81618

Anti-FAM91A1 antibody

3

(3 Reviews)

|

(1 Publication)

Rabbit Polyclonal FAM91A1 antibody. Suitable for IP and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human FAM91A1 aa 300-350.

View Alternative Names

Protein FAM91A1, FAM91A1

1 Images
Immunoprecipitation - Anti-FAM91A1 antibody (AB81618)
  • IP

Unknown

Immunoprecipitation - Anti-FAM91A1 antibody (AB81618)

Detection of FAM91A1 by Western Blot of immunoprecipitates in whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells. ab81618 was used for IP at 3 μg/mg lysate (lane 1). Lane 2 represents control IgG. Detection was by chemiluminescence with an exposure time of 3 seconds.

All lanes:

Immunoprecipitation - Anti-FAM91A1 antibody (ab81618)

Predicted band size: 94 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IP

applications

Immunogen

Synthetic Peptide within Human FAM91A1 aa 300-350. The exact immunogen used to generate this antibody is proprietary information.

Q658Y4

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "2-5 µg/mg of lysate", "IP-species-notes": "<p></p>" }, "Mouse": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "" }, "Rat": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "" }, "Chicken": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "" }, "Chimpanzee": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "" }, "Dog": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "" }, "Gorilla": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "" }, "Guinea pig": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "" }, "Horse": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "" }, "Orangutan": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "" }, "Pig": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "" }, "Platypus": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "" }, "Rabbit": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "" }, "Rhesus monkey": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "" }, "Turkey": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "" }, "Xenopus tropicalis": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab81618 was affinity purified using an epitope specific to FAM91A1 immobilized on solid support.
Storage buffer
pH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: PBS, 1.815% Tris, 1.764% Sodium citrate
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protein FAM91A1 also known as Family with Sequence Similarity 91 Member A1 is involved in intracellular processes related to membrane trafficking. It has an approximate molecular mass of 67 kDa. Its expression is mainly observed in tissues like the brain where it may play a role in neurodevelopment. Although its distribution is widespread higher expression levels occur in tissues with dynamic intracellular transit such as the kidney and liver.
Biological function summary

This protein participates in cellular functions that involve endosomal trafficking and recycling. FAM91A1 interacts with other proteins to form complexes that regulate cargo sorting within cells. Its mechanical involvement in vesicular transport is important for maintaining cellular homeostasis. Due to its interaction with several membrane-coupled proteins it influences cellular organization and signaling.

Pathways

FAM91A1 is involved in the endocytic pathway and the lysosomal pathway. It collaborates with proteins such as Rab GTPases which are key regulators of vesicular transport. The connection of FAM91A1 to these pathways reflects its role in determining the fate of endocytosed material and influencing lysosome-related processes. It also interfaces with clathrin-coated vesicle components facilitating endosome maturation and delivery to lysosomes.

FAM91A1 has connections to neurodegenerative diseases and cancer. Studies suggest that its dysregulation can contribute to Alzheimer's disease through interaction with proteins like amyloid precursor protein (APP) impacting amyloid-beta processing. Additionally its altered expression is observed in certain cancers linking it to proteins involved in tumor metastasis such as matrix metalloproteinases. These connections underline its potential as a biomarker in disease diagnosis and therapy.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1.
See full target information FAM91A1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 9:596 PubMed29426865

2018

The WDR11 complex facilitates the tethering of AP-1-derived vesicles.

Applications

Unspecified application

Species

Unspecified reactive species

Paloma Navarro Negredo,James R Edgar,Paul T Manna,Robin Antrobus,Margaret S Robinson
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Product promise

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