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AB186671

Anti-Fas Ligand antibody

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(4 Publications)

Goat Polyclonal Fas Ligand antibody. Suitable for WB, sELISA, IHC-P, FuncS (Neut/Block) and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human FASLG.

View Alternative Names

CD178, APT1LG1, CD95L, FASL, TNFSF6, FASLG, Tumor necrosis factor ligand superfamily member 6, Apoptosis antigen ligand, CD95 ligand, Fas antigen ligand, APTL, CD95-L, Fas ligand, FasL

Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, FuncS (Neut/Block), sELISA, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human FASLG.

P48023

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "sELISA" : {"fullname" : "Sandwich ELISA", "shortname":"sELISA"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "FuncSNeutBlock" : {"fullname" : "Functional Studies (Neut/Block)", "shortname":"FuncS (Neut/Block)"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "sELISA-species-checked": "guaranteed", "sELISA-species-dilution-info": "", "sELISA-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "FuncSNeutBlock-species-checked": "guaranteed", "FuncSNeutBlock-species-dilution-info": "", "FuncSNeutBlock-species-notes": "<p>ab186671 at a concentration of 0.08 - 0.1 ug/ml yields one-half maximal inhibition [ND50] of the biological activity of Fas Ligand (10 ng/ml).</p>" } } }
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Product details

Although some customers have been successful in IHC we no longer batch test in this application.
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Properties and storage information

Form
Lyophilized
Reconstitution
Reconstitute in water
Purification technique
Affinity purification Immunogen
Purification notes
ab186671 was purified by affinity chromatography employing immobilized Human Fas Ligand/Apo1L matrix.
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells (PubMed : 26334989, PubMed : 9228058). Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development (PubMed : 7528780, PubMed : 9228058, PubMed : 9427603). Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses (By similarity). TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance (By similarity). Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis (PubMed : 27806260).. Tumor necrosis factor ligand superfamily member 6, soluble form. Induces FAS-mediated activation of NF-kappa-B, initiating non-apoptotic signaling pathways (By similarity). Can induce apoptosis but does not appear to be essential for this process (PubMed : 27806260).. FasL intracellular domain. Cytoplasmic form induces gene transcription inhibition.
See full target information FASLG
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 23: PubMed36293411

2022

Relationship between Neuroglial Apoptosis and Neuroinflammation in the Epileptic Focus of the Brain and in the Blood of Patients with Drug-Resistant Epilepsy.

Applications

Unspecified application

Species

Unspecified reactive species

Tatiana V Sokolova,Yulia M Zabrodskaya,Anastasia V Litovchenko,Natalia M Paramonova,Vugar R Kasumov,Svetlana V Kravtsova,Ekaterina N Skiteva,Daria A Sitovskaya,Elena D Bazhanova

Stem cell research & therapy 12:169 PubMed33691791

2021

Transcriptional factor FoxM1-activated microRNA-335-3p maintains the self-renewal of neural stem cells by inhibiting p53 signaling pathway via Fmr1.

Applications

Unspecified application

Species

Unspecified reactive species

Jiaoying Jia,Yan Cui,Zhigang Tan,Min Liu,Yugang Jiang

Nature communications 11:6352 PubMed33311518

2020

An immune checkpoint score system for prognostic evaluation and adjuvant chemotherapy selection in gastric cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Jia-Bin Wang,Ping Li,Xiao-Long Liu,Qiao-Ling Zheng,Yu-Bin Ma,Ya-Jun Zhao,Jian-Wei Xie,Jian-Xian Lin,Jun Lu,Qi-Yue Chen,Long-Long Cao,Mi Lin,Li-Chao Liu,Ning-Zi Lian,Ying-Hong Yang,Chang-Ming Huang,Chao-Hui Zheng

Molecular medicine reports 18:1560-1570 PubMed29901074

2018

Apigenin suppresses the apoptosis of H9C2 rat cardiomyocytes subjected to myocardial ischemia‑reperfusion injury via upregulation of the PI3K/Akt pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Zhengwen Zhou,Yue Zhang,Luning Lin,Jianmei Zhou
View all publications
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