Anti-Fas Ligand antibody [MFL3] - Low endotoxin, Azide free

Target data

Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells (PubMed : 7511063). Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development (PubMed : 19794494, PubMed : 7532682). Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses (PubMed : 19794494). TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance (PubMed : 10779162). Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis (By similarity).. Tumor necrosis factor ligand superfamily member 6, soluble form. Induces FAS-mediated activation of NF-kappa-B, initiating non-apoptotic signaling pathways (PubMed : 19794494). Can induce apoptosis but does not appear to be essential for this process (By similarity).. FasL intracellular domain. Cytoplasmic form induces gene transcription inhibition.