Rabbit Polyclonal FASTKD5 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human FASTKD5.
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- Nature immunology 22:423-4332021Multi-omics analyses reveal that HIV-1 alters CD4 T cell immunometabolism to fuel virus replication.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHaitao Guo,Qi Wang,Khader Ghneim,Li Wang,Elena Rampanelli,Elizabeth Holley-Guthrie,Liang Cheng,Carolina Garrido,David M Margolis,Leigh A Eller,Merlin L Robb,Rafick-Pierre Sekaly,Xian Chen,Lishan Su,Jenny P-Y TingPubMed 33767427
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 78.99% PBS, 20% Glycerol (glycerin, glycerine), 1% BSA- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human FASTKD5. The exact immunogen used to generate this antibody is proprietary information. Database link Q7L8L6
Reactivity data
Select an application| WB | IHC-P | |
|---|---|---|
| Human | Tested | Tested |
| Monkey | Predicted | Predicted |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Monkey | Dilution info - | Notes - |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info - | Notes Perform heat mediated antigen retrieval with 10 mM citrate buffer pH 6 or Tris-EDTA buffer (pH 8.0) before commencing with IHC staining protocol. |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Monkey | Dilution info - | Notes - |
Target data
Function
Plays an important role in the processing of non-canonical mitochondrial mRNA precursors (PubMed:25683715).
Alternative names
KIAA1792, FASTKD5
Recommended products
Rabbit Polyclonal FASTKD5 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human FASTKD5.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 78.99% PBS, 20% Glycerol (glycerin, glycerine), 1% BSA- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human FASTKD5. The exact immunogen used to generate this antibody is proprietary information. Database link Q7L8L6
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
FASTKD5 also known as FAST kinase domain-containing protein 5 is a mitochondrial protein that plays a role in the processing and translation of mitochondrial mRNAs. It has a mass of approximately 87 kDa. This protein is highly expressed in tissues with high energy demands such as the heart skeletal muscle and brain. FASTKD5 contains a FAST kinase-like domain that is important for its function in the mitochondria.
- Biological function summary
FASTKD5 is involved in maintaining mitochondrial homeostasis and function. It is part of the FASTKD family which consists of proteins that have similar domains and functions in the mitochondria. FASTKD5 is believed to interact with other proteins to form complexes that regulate mitochondrial RNA metabolism. This regulation is important for ensuring the correct expression of mitochondrial genes which are essential for energy production and cellular metabolism.
- Pathways
FASTKD5 fits into mitochondrial RNA processing and oxidative phosphorylation pathways. It is key for processing of precursor RNAs in mitochondria which are vital for the assembly and function of the electron transport chain. FASTKD5 shows interactions with other mitochondrial proteins such as FASTKD2 which also participates in mitochondrial RNA processing. Disruptions in these pathways can lead to compromised cellular energy metabolism.
- Associated diseases and disorders
FASTKD5 links to conditions that involve mitochondrial dysfunction such as mitochondrial encephalomyopathy and cardiomyopathy. Mutations affecting FASTKD5 can contribute to insufficient energy production in cells leading to symptoms associated with these disorders. Additionally disturbances in FASTKD5 function can influence the expression and function of other mitochondrial proteins like FASTKD3 exacerbating energy production issues and disease symptoms.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
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2 product images
Western blot - Anti-FASTKD5 antibody (ab111548)
7.5% SDS PAGE
All lanes: Western blot - Anti-FASTKD5 antibody (ab111548) at 1/1000 dilution
All lanes: A431 whole cell lysate at 30 µg
Predicted band size: 87 kDa
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FASTKD5 antibody (ab111548)
ab111548 at 1:500 dilution staining FASTKD5 by IHC-P (hepatoma).
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