Rabbit Polyclonal FAT/FAT1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human FAT1.
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- Journal of the American Society of Nephrology : JASN 33:1033-10442022Hematopoietic Stem Cell Transplant-Membranous Nephropathy Is Associated with Protocadherin FAT1.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSanjeev Sethi,Benjamin Madden,Marta Casal Moura,Samih H Nasr,Nattawat Klomjit,LouAnn Gross,Vivian Negron,M Cristine Charlesworth,Mariam P Alexander,Nelson Leung,Ulrich Specks,Fernando C Fervenza,Mark HaasPubMed 35321939
- Analytical cellular pathology (Amsterdam) 2021:92903722021FAT1 and PTPN14 Regulate the Malignant Progression and Chemotherapy Resistance of Esophageal Cancer through the Hippo Signaling Pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYingzhi Lu,Zhenxin Wang,Ling Zhou,Zhaoming Ma,Jianguo Zhang,Yan Wu,Yan Shao,Yunyun YangPubMed 34712552
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human FAT1. The exact immunogen used to generate this antibody is proprietary information. Database link Q14517
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/50.00000 - 1/200.00000 | Notes - |
Associated Products
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1 product for Alternative Product
Target data
Function
Protocadherin Fat 1. Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact.
Alternative names
CDHF7, FAT, FAT1, Protocadherin Fat 1, Cadherin family member 7, Cadherin-related tumor suppressor homolog, Protein fat homolog
Recommended products
Rabbit Polyclonal FAT/FAT1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human FAT1.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human FAT1. The exact immunogen used to generate this antibody is proprietary information. Database link Q14517
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
FAT/FAT1 also known as FAT1 cadherin is a large transmembrane protein encoded by the FAT1 gene. It has a molecular weight of roughly 506 kDa. This protein is characterized by its cadherin-like domains and is widely expressed in various tissues including the brain kidney and skin. FAT1 is involved in cell adhesion processes and plays a critical role in the maintenance of cell shape and polarity.
- Biological function summary
This protein participates in development and morphogenesis. FAT1 functions as a part of the cell adhesion complex interacting with actin cytoskeleton components. It also influences cellular behavior such as migration and proliferation. Through its interactions FAT1 contributes to the mechanical stability and structural integrity of cells within tissues.
- Pathways
FAT1 interacts with signaling cascades implicated in cytoskeletal reorganization and cellular communication. It is notably involved in the Wnt signaling pathway and the Hippo pathway which are key in cell proliferation and growth regulation. Other related proteins in these pathways include beta-catenin and YAP/TAZ which mediate the downstream effects of these signaling pathways.
- Associated diseases and disorders
Alterations in FAT1 expression or function have been associated with cancer and renal disorders. Mutations or dysregulation of FAT1 can lead to disrupted cellular processes contributing to tumorigenesis and kidney disease. It is closely connected to proteins such as p53 in the context of cancer where p53 plays a role in controlling cell cycle progression and apoptosis in response to genomic instability.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FAT/FAT1 antibody (ab198892)
Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue labeling FAT/FAT1 with ab198892 at 1/40 dilution.
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