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AB198861

Anti-FAT3 antibody

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(1 Publication)

Rabbit Polyclonal FAT3 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human FAT3.

View Alternative Names

CDHF15, KIAA1989, FAT3, Protocadherin Fat 3, hFat3, Cadherin family member 15, FAT tumor suppressor homolog 3

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FAT3 antibody (AB198861)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FAT3 antibody (AB198861)

Immmunohistochemical analysis of formalin-fixed, paraffin-embedded Human liver cancer tissue labeling FAT3 with ab198861 at 1/20 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FAT3 antibody (AB198861)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FAT3 antibody (AB198861)

Immmunohistochemical analysis of formalin-fixed, paraffin-embedded Human thyroid cancer tissue labeling FAT3 with ab198861 at 1/20 dilution.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human FAT3. The exact immunogen used to generate this antibody is proprietary information.

Q8TDW7

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/25 - 1/100", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol." }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The FAT3 protein also known as FAT atypical cadherin 3 functions mechanically as a transmembrane protein involved in cell adhesion. It belongs to the cadherin superfamily and is part of the larger protocadherin family. FAT3 has a significant molecular mass of approximately 600-660 kDa making it one of the largest cadherins. This protein expresses highly in the nervous system particularly in the brain where it plays a role in the development and organization of neural circuits.
Biological function summary

FAT3 plays an important role in the regulation of cell-cell interactions and is essential for neural development. It does not function as a monomer; it interacts as part of a larger protein complex that includes other cadherins and associated proteins. The absence or mutation of FAT3 can lead to disrupted cell signaling and morphology indicating its significant role in maintaining cellular architecture.

Pathways

FAT3 is intricately involved in pathways bridging cell signaling and adhesion notably the Wnt signaling pathway. The Wnt pathway regulates cell fate determination and stem cell maintenance and FAT3 interacts with proteins like beta-catenin that partake in this pathway. This interaction strengthens the role of FAT3 in managing cellular communications and maintaining cellular architecture.

FAT3 connections to nervous system-related disorders are prominent particularly in neurodevelopmental and neuropsychiatric conditions such as autism and epilepsy. The disruption of FAT3 functional pathways can affect neurodevelopment with contributory proteins like CSTB and CTNNB1 drawing a link to disease mechanisms. These associations highlight the potential importance of FAT3 in understanding and possibly managing certain neurological disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May play a role in the interactions between neurites derived from specific subsets of neurons during development.
See full target information FAT3
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of biochemical and molecular toxicology 38:e23688 PubMed38511888

2024

CD93 regulates breast cancer growth and vasculogenic mimicry through the PI3K/AKT/SP2 signaling pathway activated by integrin β1.

Applications

Unspecified application

Species

Unspecified reactive species

Hong Liu,Jianhui Zhang,Yanjun Zhao,Zhixiong Fan,Yongheng Yang,Yuanyuan Mao,Jingyuan Yang,Shungao Ma
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Product promise

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