Anti-FAT3 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The FAT3 protein also known as FAT atypical cadherin 3 functions mechanically as a transmembrane protein involved in cell adhesion. It belongs to the cadherin superfamily and is part of the larger protocadherin family. FAT3 has a significant molecular mass of approximately 600-660 kDa making it one of the largest cadherins. This protein expresses highly in the nervous system particularly in the brain where it plays a role in the development and organization of neural circuits.

Biological function summary

FAT3 plays an important role in the regulation of cell-cell interactions and is essential for neural development. It does not function as a monomer; it interacts as part of a larger protein complex that includes other cadherins and associated proteins. The absence or mutation of FAT3 can lead to disrupted cell signaling and morphology indicating its significant role in maintaining cellular architecture.

Pathways

FAT3 is intricately involved in pathways bridging cell signaling and adhesion notably the Wnt signaling pathway. The Wnt pathway regulates cell fate determination and stem cell maintenance and FAT3 interacts with proteins like beta-catenin that partake in this pathway. This interaction strengthens the role of FAT3 in managing cellular communications and maintaining cellular architecture.

Associated diseases and disorders

FAT3 connections to nervous system-related disorders are prominent particularly in neurodevelopmental and neuropsychiatric conditions such as autism and epilepsy. The disruption of FAT3 functional pathways can affect neurodevelopment with contributory proteins like CSTB and CTNNB1 drawing a link to disease mechanisms. These associations highlight the potential importance of FAT3 in understanding and possibly managing certain neurological disorders.