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AB223720

Anti-FATE1 antibody

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(1 Publication)

Rabbit Polyclonal FATE1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human FATE1 aa 50 to C-terminus.

View Alternative Names

FATE, FATE1, Fetal and adult testis-expressed transcript protein, Cancer/testis antigen 43, Tumor antigen BJ-HCC-2, CT43

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FATE1 antibody (AB223720)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FATE1 antibody (AB223720)

Paraffin-embedded human testis tissue stained for FATE1 using ab223720 at 1/1000 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human FATE1 aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q969F0

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/1000 - 1/2500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protein known as FATE1 also called "fetal and adult testis expressed 1" is involved in cellular mechanics by participating in cell survival processes. This protein has a molecular mass of approximately 23 kDa. You can find FATE1 mainly expressed in testis tissue but it is also observed in certain tumors. Its expression in tumors makes it a target of interest for cancer research. FATE1 plays a role in the regulation of the endoplasmic reticulum (ER) and mitochondria interactions influencing cellular homeostasis.
Biological function summary

FATE1 contributes to cancer cell survival by regulating apoptosis and cell proliferation. It does not function as part of a larger protein complex. Instead it acts independently to modulate the apoptotic pathways. By interacting with the mitochondria-associated membranes FATE1 influences calcium signaling which impacts cell viability and response to stress. This role in apoptosis regulation makes it an area of focus in the study of cancer progression and metastasis.

Pathways

Scientists have observed FATE1 in its relationship with the mitochondrial apoptosis pathway as well as its involvement in calcium signaling pathways. It interacts with proteins such as Bcl-2 which are regulators of apoptosis. The connection of FATE1 to these pathways highlights its central role in maintaining mitochondrial function and integrity which are important for cell survival and adaptation under stress conditions.

Researchers associate FATE1 with certain types of cancer particularly testicular cancer and some other malignancies through its expression in tumor cells. FATE1 expression has shown correlation with cancer progression and poor prognosis making it a potential biomarker and therapeutic target. Additionally its dysregulation can interact with the protein p53 a well-known tumor suppressor suggesting a functional relationship that could influence tumor growth and response to treatment.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Involved in the regulation of endoplasmic reticulum (ER)-mitochondria coupling. Negatively regulates the ER-mitochondria distance and Ca(2+) transfer from ER to mitochondria possibly implicating it in the regulation of apoptosis (PubMed : 27402544). May collaborate with RNF183 to restrain BIK protein levels thus regulating apoptotic signaling (PubMed : 26567849).
See full target information FATE1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

JCI insight 9: PubMed39315548

2024

Pyruvate metabolism dictates fibroblast sensitivity to GLS1 inhibition during fibrogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Greg Contento,Jo-Anne Am Wilson,Brintha Selvarajah,Manuela Platé,Delphine Guillotin,Valle Morales,Marcello Trevisani,Vanessa Pitozzi,Katiuscia Bianchi,Rachel C Chambers
View all publications
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Product promise

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