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AB69458

Anti-FATP1 antibody

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(7 Publications)

Mouse Polyclonal FATP1 antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human SLC27A1.

View Alternative Names

ACSVL5, FATP1, SLC27A1, Long-chain fatty acid transport protein 1, Arachidonate--CoA ligase, Fatty acid transport protein 1, Long-chain-fatty-acid--CoA ligase, Solute carrier family 27 member 1, Very long-chain acyl-CoA synthetase, FATP-1

1 Images
Western blot - Anti-FATP1 antibody (AB69458)
  • WB

Unknown

Western blot - Anti-FATP1 antibody (AB69458)

All lanes:

Western blot - Anti-FATP1 antibody (ab69458) at 1/500 dilution

Lane 1:

SLC27A1 transfected 293T lysate at 25 µg

Lane 2:

Non-transfected 293T lysate at 25 µg

Secondary

All lanes:

Goat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

Predicted band size: 71 kDa

Observed band size: 71 kDa

false

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human SLC27A1.

Q6PCB7

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Anti-RAB27B antibody [EPR28647-45]

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  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FATP1 also known as Slc27a1 stands for Fatty Acid Transport Protein 1 and plays a significant role in fatty acid uptake and metabolism. It functions as a transporter that facilitates the influx of long-chain fatty acids across cell membranes. FATP1 weighs approximately 63 kDa and exhibits expression mainly in adipose tissue muscle and liver. The presence of FATP1 in these tissues suggests a specialized involvement in energy metabolism and storage processes.
Biological function summary

FATP1 supports critical processes in lipid metabolism and energy balance. It is not just a flexible transporter of fatty acids but also plays a role in the activation of these molecules through acyl-CoA synthetase activity. FATP1 associates with other metabolic enzymes to form functional complexes that optimize lipid utilization. Through these activities FATP1 influences cellular lipid composition and energy homeostasis with significant effects on metabolic health.

Pathways

FATP1 integrates into the intricate network of lipid metabolism and energy pathways. It is linked with the peroxisome proliferator-activated receptor (PPAR) signaling pathway which regulates lipid metabolism and glucose homeostasis. FATP1 interacts with proteins like CD36 and acyl-CoA synthetase long-chain family members enhancing its role in fatty acid uptake and contributing to efficient metabolic processes.

FATP1 shows associations with metabolic syndromes like obesity and type 2 diabetes. Its altered activity or expression contributes to impaired lipid metabolism thereby aggravating these conditions. FATP1 also has connections with proteins like insulin receptor substrate 1 (IRS1) where dysregulation affects insulin signaling pathways. Understanding FATP1's functions and interactions provides insights into potential therapeutic targets for managing metabolic disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport at the plasma membrane (PubMed : 12556534, PubMed : 20530735, PubMed : 21395585, PubMed : 28178239). Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism (By similarity). Probably involved in fatty acid transport across the blood barrier (PubMed : 21395585).
See full target information SLC27A1
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Publications (7)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 13:3728 PubMed35764645

2022

MYCN-driven fatty acid uptake is a metabolic vulnerability in neuroblastoma.

Applications

Unspecified application

Species

Unspecified reactive species

Ling Tao,Mahmoud A Mohammad,Giorgio Milazzo,Myrthala Moreno-Smith,Tajhal D Patel,Barry Zorman,Andrew Badachhape,Blanca E Hernandez,Amber B Wolf,Zihua Zeng,Jennifer H Foster,Sara Aloisi,Pavel Sumazin,Youli Zu,John Hicks,Ketan B Ghaghada,Nagireddy Putluri,Giovanni Perini,Cristian Coarfa,Eveline Barbieri

Frontiers in oncology 11:737127 PubMed34976793

2021

Multi-Omics Analysis of Fatty Acid Metabolism in Thyroid Carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Jinghui Lu,Yankun Zhang,Min Sun,Changyuan Ding,Lei Zhang,Youzi Kong,Meng Cai,Paolo Miccoli,Chunhong Ma,Xuetian Yue

Advances in radiation oncology 5:994-1005 PubMed33083663

2020

Cytotoxicity and Radiosensitizing Activity of the Fatty Acid Synthase Inhibitor C75 Is Enhanced by Blocking Fatty Acid Uptake in Prostate Cancer Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Colin Rae,Georgios I Fragkoulis,Anthony J Chalmers

Cellular physiology and biochemistry : internation 52:94-108 PubMed30790507

2019

Linoleic Acid Increases Prostaglandin E2 Release and Reduces Mitochondrial Respiration and Cell Viability in Human Trophoblast-Like Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Nirajan Shrestha,James S M Cuffe,Olivia J Holland,Anthony V Perkins,Andrew J McAinch,Deanne H Hryciw

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 33:738-749 PubMed30020829

2018

Secretory phospholipase A group IIA enhances the metabolic rate and increases glucose utilization in response to thyroid hormone.

Applications

Unspecified application

Species

Unspecified reactive species

Michael S Kuefner,Xiong Deng,Erin J Stephenson,Kevin Pham,Edwards A Park

Cell death & disease 7:e2487 PubMed27882945

2016

Adiponectin reduces ER stress-induced apoptosis through PPARα transcriptional regulation of ATF2 in mouse adipose.

Applications

WB

Species

Unspecified reactive species

Zhenjiang Liu,Lu Gan,Tianjiao Wu,Fei Feng,Dan Luo,Huihui Gu,Shimin Liu,Chao Sun

The British journal of nutrition 111:445-51 PubMed23947577

2013

n-6:n-3 PUFA ratio is involved in regulating lipid metabolism and inflammation in pigs.

Applications

Unspecified application

Species

Unspecified reactive species

Yehui Duan,Fengna Li,Lili Li,Juexin Fan,Xiaoming Sun,Yulong Yin
View all publications
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Product promise

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