AB234835

Anti-FAU / 40S ribosomal protein S30 antibody

Name: Anti-FAU / 40S ribosomal protein S30 antibody (ab234835) | Abcam
Brand: Abcam Limited
SKU: AB234835

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(1 Publication)

Rabbit Polyclonal RS30 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human FAU.

View Alternative Names

Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein, FAU ubiquitin like and ribosomal protein S30 fusion, FAU

3 Images

Immunocytochemistry/ Immunofluorescence - Anti-FAU / 40S ribosomal protein S30 antibody (AB234835)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-FAU / 40S ribosomal protein S30 antibody (AB234835)

HeLa (Human epithelial cell line from cervix adenocarcinoma) cells stained for FAU / 40S ribosomal protein S30 (Green) using ab234835 at 1/100 dilution in ICC/IF. Secondary used is an Alexa-Fluor^®488-conjugated Goat Anti-Rabbit IgG (H+L).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FAU / 40S ribosomal protein S30 antibody (AB234835)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FAU / 40S ribosomal protein S30 antibody (AB234835)

Paraffin-embedded human endometrial cancer tissue stained for FAU / 40S ribosomal protein S30 using ab234835 at 1/100 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FAU / 40S ribosomal protein S30 antibody (AB234835)

Paraffin-embedded human colon cancer tissue stained for FAU / 40S ribosomal protein S30 using ab234835 at 1/100 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

ICC/IF, IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Human FAU.

P62861

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein G

Purification notes

Purity >95%.

Storage buffer

pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The FAU protein also known as 40S ribosomal protein S30 plays an important role in the formation of ribosomes which are essential for protein synthesis. With a molecular mass of approximately 13 kDa it contributes to the small subunit of the ribosome assembly. This protein is expressed in several tissues including the liver kidney and pancreas indicating its ubiquitous role in maintaining cellular machinery. The FAU gene encodes this protein and its expression shows variation depending on tissue type and physiological conditions.

Biological function summary

FAU / 40S ribosomal protein S30 is a component of the eukaryotic ribosomal 40S subunit participating in the translation process. It forms part of the ribosome complex with other ribosomal proteins and RNA which together drive the synthesis of proteins in cells by translating mRNA. Its role in ribosome assembly emphasizes its involvement in the overall cellular function of protein production which is fundamental for cell growth and division.

Pathways

FAU protein integrates mainly within the process of translational initiation. The process includes various steps where the protein joins other ribosomal proteins and initiation factors to form functional ribosomes that start the translation of mRNA. FAU's interactions include associations with proteins like eIF3 an essential initiation factor which facilitates the accurate translation start site selection. This engagement ensures that FAU is integral to both the regulation and efficiency of protein synthesis a critical cellular activity.

FAU / 40S ribosomal protein S30 connects with certain cancers reflecting its importance in cell proliferation. Changes in FAU expression levels associate with malignant transformation particularly in liver cancer suggesting its potential role in tumor development. It also interacts with P53 a well-known tumor suppressor protein highlighting its relevance in apoptosis and cancer-related pathways. Additionally its altered regulation associates with ribosomopathies which are disorders arising from defects in ribosomal function underlining its essential contributions to cellular homeostasis and health.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

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Target data

Ubiquitin-like protein FUBI. May have pro-apoptotic activity.. Small ribosomal subunit protein eS30. Component of the 40S subunit of the ribosome. Contributes to the assembly and function of 40S ribosomal subunits.

See full target information FAU

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

The American journal of pathology 193:1156-1169 PubMed37263345

2023

Development of Scaffold-Free Three-Dimensional Cholangiocyte Organoids to Study the Progression of Primary Sclerosing Cholangitis.

Applications

Unspecified application

Species

Unspecified reactive species

Wenjun Zhang,Konstantina Kyritsi,Abdulkadir Isidan,Yujin Park,Ping Li,Arthur A Cross-Najafi,Kevin Lopez,Lindsey Kennedy,Keisaku Sato,Shannon Glaser,Heather Francis,Gianfranco Alpini,Burcin Ekser

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-FAU / 40S ribosomal protein S30 antibody

Immunocytochemistry/ Immunofluorescence - Anti-FAU / 40S ribosomal protein S30 antibody (AB234835)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FAU / 40S ribosomal protein S30 antibody (AB234835)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FAU / 40S ribosomal protein S30 antibody (AB234835)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Secondary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

Product promise