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AB151065

Anti-FBN3 antibody

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(1 Publication)

Rabbit Polyclonal FBN3 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human FBN3 aa 250-350.

View Alternative Names

KIAA1776, FBN3, Fibrillin-3

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FBN3 antibody (AB151065)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FBN3 antibody (AB151065)

Immunohistochemical analysis of paraffin-embedded Human kidney tissue labeling FBN3 with ab151065 at 1/50 dilution.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human FBN3 aa 250-350. The exact immunogen used to generate this antibody is proprietary information.

Q75N90

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }
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Product details

The antibody solution should be gently mixed before use.
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FBN3 also known as Fibrillin-3 is a glycoprotein with a mass of approximately 350 kDa. It belongs to the fibrillin family of proteins which are essential components of the extracellular matrix. FBN3 is predominantly expressed in the fetal and adult brain as well as the adrenal gland. These expression patterns suggest its potential role in neural development and function although the full spectrum of its expression remains to be completely defined.
Biological function summary

FBN3 plays a major role in the structure and function of connective tissues. It often combines with other fibrillin proteins to form microfibrils. Microfibrils contribute to the structural integrity and elasticity of tissues. The ability of FBN3 to interact with other components of the extracellular matrix including elastin positions it as an important element in maintaining the physical properties of tissues especially those requiring resilience such as skin and heart tissues.

Pathways

FBN3 participates in the TGF-beta signaling pathway which regulates cell growth proliferation and differentiation. The protein interacts with other members of the fibrillin family especially FBN1 and FBN2 within these pathways. Its engagement in such pathways highlights its role in regulating extracellular matrix formation. Also FBN3 contributes to maintaining tissue homeostasis highlighting its significant part in developmental processes.

Alterations in FBN3 expression or function link to Marfan syndrome a genetic disorder affecting connective tissue integrity and idiopathic scoliosis a condition characterized by abnormal spine curvature. Similar to its family members FBN3 interacts with FBN1 affecting connective tissue properties in these diseases. Understanding FBN3's role opens potential therapeutic avenues for these and possibly other connective tissue disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Fibrillin-3. Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-containing microfibrils provide long-term force bearing structural support.
See full target information FBN3
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cancer cell international 22:231 PubMed35854294

2022

Depleting TMED3 alleviates the development of endometrial carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Jin Zhang,Yue Qi
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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