AB113961

Anti-FBP17 antibody

Name: Anti-FBP17 antibody (ab113961) | Abcam
Brand: Abcam Limited
SKU: AB113961
Price: 565 USD
Availability: InStock

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(1 Publication)

Goat Polyclonal FBP17 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human FNBP1 aa 100-150.

View Alternative Names

FBP17, KIAA0554, FNBP1, Formin-binding protein 1, Formin-binding protein 17, hFBP17

3 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FBP17 antibody (AB113961)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FBP17 antibody (AB113961)

Immunohistochemical staining of Human Tonsil using ab113961 at 3.75μg/ml

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FBP17 antibody (AB113961)

Immunohistochemical staining of Human Small Intestine using ab113961 at 3.75μg/ml

Unknown

Western blot - Anti-FBP17 antibody (AB113961)

Primary incubated for 1 hour.

All lanes:

Western blot - Anti-FBP17 antibody (ab113961) at 0.25 µg/mL

All lanes:

Human testis lysate at 35 µg

Predicted band size: 71 kDa

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Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human FNBP1 aa 100-150. The exact immunogen used to generate this antibody is proprietary information.

Q96RU3

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.25-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "3.75 µg/mL", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Chicken": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Dog": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Horse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Pig": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rabbit": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Zebrafish": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.3 Preservative: 0.02% Sodium azide Constituents: 99% Tris buffered saline, 0.5% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FBP17 formally known as Formin-binding protein 17 is a protein with a molecular mass of approximately 59 kDa. It features an F-BAR domain that facilitates membrane bending and cytoskeletal organization. Expressed mainly in neural tissues FBP17 affects the dynamics of the cell membrane and is involved in the formation of tubular structures critical for various cellular processes. Researchers classify it as an important player in endocytosis where its role is mechanical and structural within the cell.

Biological function summary

In cellular environments where signal transduction is occurring FBP17 engages in the regulation of actin polymerization. It participates in complex formations with other proteins like Bin2 and is important for the recruitment of actin nucleators. These interactions help in directing changes to cellular structure during activities such as migration and division. FBP17 can also influence the intracellular trafficking of signals further impacting how cells react to environmental stimuli.

Pathways

Where cell interactions and signaling occur FBP17 integrates into the pathways of actin cytoskeleton reorganization and endocytosis. It works alongside proteins like Cdc42 to modulate these pathways contributing significantly to cellular morphology adjustments and the uptake of external materials. In these processes changes in actin dynamics facilitated by FBP17 and its pathway partners provide the cellular capacity for movement and the intake of necessary substances.

Wherein cellular malfunctions manifest FBP17 has been linked to neurodegenerative diseases including Charcot-Marie-Tooth disease. In this context disruptions in FBP17 functions can alter cellular homeostasis leading to neurodegeneration. Additionally FBP17 associates with amphiphysin impacting stress response pathways and signaling which are often implicated in cancer. Understanding FBP17's role may offer insights into these diseases and guide therapeutic strategies.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
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Target data

May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL.

See full target information FNBP1

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

The Journal of biological chemistry 292:16970-16982 PubMed28864775

2017

Proteolytic processing of lysyl oxidase-like-2 in the extracellular matrix is required for crosslinking of basement membrane collagen IV.

Applications

Unspecified application

Species

Unspecified reactive species

Alberto J López-Jiménez,Trayambak Basak,Roberto M Vanacore

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-FBP17 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FBP17 antibody (AB113961)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FBP17 antibody (AB113961)

Western blot - Anti-FBP17 antibody (AB113961)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

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