Rabbit Polyclonal FBP2 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human FBP2 aa 250 to C-terminus.
View Alternative Names
FBPase 2, Muscle FBPase, FBP2
- ICC/IF
Supplier Data
Immunocytochemistry/ Immunofluorescence - Anti-FBP2 antibody (AB236660)
HepG2 (human liver hepatocellular carcinoma cell line) cells stained for FBP2 using ab236660 at a dilution of 1/166 in ICC/IF.
The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal goat serum. The cells were then incubated with the primary antibody overnight at 4°C. Secondary used is an Alexa-Fluor®488-conjugated Goat Anti-Rabbit IgG (H+L).
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Reactivity data
Properties and storage information
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Supplementary information
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Biological function summary
The enzyme plays a role in glucose homeostasis by regulating gluconeogenesis. It is a part of the fructose-16-bisphosphatase complex that controls the balance between glycolysis and gluconeogenesis. FBP2 activity helps to maintain blood glucose levels particularly during periods of fasting or intense physical activity. By adjusting the rate of glucose production and consumption the enzyme contributes to metabolic flexibility.
Pathways
FBP2 functions in the regulation of the gluconeogenesis pathway. This pathway is key in maintaining normal blood glucose levels and the enzyme acts in coordination with related enzymes like glucose-6-phosphatase. FBP2 is involved in the balance between glycolysis and gluconeogenesis partnering with enzymes such as phosphofructokinase which perform opposite functions to regulate energy production and consumption. This fine-tuning of energy pathways ensures that cells have a stable supply of glucose adjusting for factors such as nutrient availability and hormonal signals.
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Publications (2)
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Histology and histopathology 38:1017-1028 PubMed36515277
2022
Applications
Unspecified application
Species
Unspecified reactive species
Cancer cell international 22:226 PubMed35804447
2022
Applications
Unspecified application
Species
Unspecified reactive species
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