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AB264403

Anti-FBSH antibody

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Rabbit Polyclonal FBSH antibody. Suitable for WB and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human FBRS aa 1-50.

View Alternative Names

FBS, FBS1, FBRS, Probable fibrosin-1

1 Images
Western blot - Anti-FBSH antibody (AB264403)
  • WB

Supplier Data

Western blot - Anti-FBSH antibody (AB264403)

Lysates prepared using NETN lysis buffer.

All lanes:

Western blot - Anti-FBSH antibody (ab264403) at 1/1000 dilution

Lane 1:

HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate at 50 µg

Lane 2:

HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate at 50 µg

Lane 3:

Jurkat (human T cell leukemia cell line from peripheral blood) whole cell lysate at 50 µg

Predicted band size: 39 kDa

true

Exposure time: 3min

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human FBRS aa 1-50. The exact immunogen used to generate this antibody is proprietary information.

Q9HAH7

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 6.8 - 7.4 Preservative: 0.09% Sodium azide Constituents: Tris buffered saline, 0.1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Follicle-Stimulating Hormone (FSH) also known as Follitropin is a glycoprotein with a molecular mass of approximately 30 kDa. FSH is secreted by the anterior pituitary gland and is composed of two subunits: a common alpha subunit and a unique beta subunit. This hormone plays an important mechanical role in regulating reproductive processes. It stimulates the growth and development of ovarian follicles in females and supports spermatogenesis in males by acting on Sertoli cells. The expression of FSH mainly occurs in cells of the gonads and the pituitary gland.
Biological function summary

FSH influences reproductive and endocrine functions. It is part of the pituitary-gonadal axis acting as a pivotal hormone that regulates gamete production and hormonal secretions. Together with Luteinizing Hormone (LH) it forms an important hormonal complex involved in the reproductive cycle. FSH binds to specific receptors on the ovaries and testes initiating intracellular signaling pathways that promote follicular growth estrogen production in females and sustenance of Sertoli cell-mediated actions in males.

Pathways

FSH participates prominently in the reproductive hormone cascade and the hypothalamic-pituitary-gonadal (HPG) axis. It interacts with the pathway controlling the menstrual and estrous cycles in females and spermatogenesis in males. The release of FSH responds to Gonadotropin-Releasing Hormone (GnRH) stimulation which also regulates LH. The coordinated actions of FSH and related family proteins such as Inhibin and Activin ensure proper feedback mechanisms are maintained for balanced reproductive health.

FSH relates closely to conditions like polycystic ovary syndrome (PCOS) and hypogonadism. PCOS often presents with abnormal levels of FSH and its counterpart LH disrupting normal ovarian function. In males low levels of FSH can lead to hypogonadism characterized by insufficient testosterone production and impaired spermatogenesis. The disease connections demonstrate FSH’s critical involvement within broader reproductive disorders with significant interactions with LH and testosterone further linking these hormonal interactions to disease mechanisms.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information FBRS
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Product promise

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