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AB111683

Anti-FBXL17 antibody

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(2 Publications)

Rabbit Polyclonal FBXL17 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human FBXL17.

View Alternative Names

FBL17, FBX13, FBXO13, FBXL17, F-box/LRR-repeat protein 17, F-box and leucine-rich repeat protein 17, F-box only protein 13

1 Images
Western blot - Anti-FBXL17 antibody (AB111683)
  • WB

Supplier Data

Western blot - Anti-FBXL17 antibody (AB111683)

Samples were separated by 10% SDS PAGE.

All lanes:

Western blot - Anti-FBXL17 antibody (ab111683) at 1/1000 dilution

Lane 1:

MCF-7 whole cell extracts at 30 µg

Lane 2:

MDA-MB-231 whole cell extracts at 30 µg

Secondary

All lanes:

HRP-conjugated anti-rabbit IgG antibody

Predicted band size: 76 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human FBXL17. The exact immunogen used to generate this antibody is proprietary information.

Q9UF56

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab111683 is purified by antigen-affinity chromatography.
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FBXL17 also known as F-box/LRR-repeat protein 17 functions as a member of the F-box protein family. These proteins form part of the SCF (SKP1-CUL1-F-box protein) complex a type of E3 ubiquitin ligase involved in protein degradation. FBXL17 has a molecular mass of approximately 49 kDa. It is expressed in various tissues with notable presence in the liver lung and kidney. By interacting with SCF FBXL17 plays a role in targeting specific substrates for ubiquitination which can regulate their stability and function.
Biological function summary

FBXL17 influences diverse processes through its role in protein ubiquitination. As a component of the SCF complex it regulates cell cycle progression and cell signaling by mediating the degradation of proteins involved in these pathways. Through protein interaction FBXL17 modulates cellular responses and assists in maintaining cellular homeostasis. It does this by recognizing and binding to phosphodegrons on substrates therefore determining their ubiquitination.

Pathways

FBXL17 interfaces with the cell cycle and signal transduction pathways. It is involved in regulating proteins like cyclins and cyclin-dependent kinases which are fundamental for cell cycle control. Additionally FBXL17 participates in the Wnt/β-catenin signaling pathway. By influencing the stability of proteins like β-catenin FBXL17 can affect gene expression and cellular activities related to these pathways.

FBXL17's dysregulation or altered expression may have connections to cancer and neurodegenerative diseases. In cancer FBXL17 can influence tumorigenesis by altering the degradation of oncoproteins and tumor suppressor genes. Its role in regulating the Wnt/β-catenin pathway associates it with disorders like colorectal cancer. FBXL17's interactions with other ubiquitin ligases such as FBXW7 may contribute to understanding its precise role in disease pathology.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Substrate-recognition component of the SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC) (PubMed : 30190310). FBXL17 specifically recognizes and binds a conserved degron of non-consecutive residues present at the interface of BTB dimers of aberrant composition : aberrant BTB dimer are then ubiquitinated by the SCF(FBXL17) complex and degraded by the proteasome (PubMed : 30190310). The ability of the SCF(FBXL17) complex to eliminate compromised BTB dimers is required for the differentiation and survival of neural crest and neuronal cells (By similarity). The SCF(FBXL17) complex mediates ubiquitination and degradation of BACH1 (PubMed : 24035498, PubMed : 30190310). The SCF(FBXL17) complex is also involved in the regulation of the hedgehog/smoothened (Hh) signaling pathway by mediating the ubiquitination and degradation of SUFU, allowing the release of GLI1 from SUFU for proper Hh signal transduction (PubMed : 27234298). The SCF(FBXL17) complex mediates ubiquitination and degradation of PRMT1 (By similarity).
See full target information FBXL17
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Stem cells international 2025:8953305 PubMed40313860

2025

Transdifferentiation of Integrin Beta 1 High+ Skin Progenitor Cells Into Functional Hepatocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Jung Hwa Lim,Dae Hun Kim,Junhee Lee,Cho-Rok Jung,Hyun Mi Kang

Journal of cell science 130:3578-3587 PubMed28883095

2017

Lipopolysaccharide modulates p300 and Sirt1 to promote PRMT1 stability via an SCF-recognized acetyldegron.

Applications

Unspecified application

Species

Unspecified reactive species

Yandong Lai,Jin Li,Xiuying Li,Chunbin Zou
View all publications
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Product promise

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