Rabbit Polyclonal FBXL18 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human FBXL18 aa 1-400.
View Alternative Names
FBL18, FBXL18, F-box/LRR-repeat protein 18, F-box and leucine-rich repeat protein 18
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FBXL18 antibody (AB239066)
Paraffin-embedded human lymphoid tissue stained for FBXL18 with ab239066 at a 1/100 dilution in immunohistochemical analysis.
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FBXL18 antibody (AB239066)
Paraffin-embedded human brain tissue stained for FBXL18 with ab239066 at a 1/100 dilution in immunohistochemical analysis.
- ICC/IF
Supplier Data
Immunocytochemistry/ Immunofluorescence - Anti-FBXL18 antibody (AB239066)
A549 (Human lung carcinoma cell line) cells stained for FBXL18 using ab239066 at a 1/100 dilution in ICC/IF. Secondary used is a Cy3-conjugated Goat Anti-Rabbit IgG.
Reactivity data
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Supplementary information
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Biological function summary
This protein regulates protein homeostasis and cellular processes by controlling the degradation of target proteins. FBXL18 forms a complex with SKP1 CUL1 and RBX1 in the SCF complex which facilitates the ubiquitination process. Through this function FBXL18 plays a role in processes like cell cycle regulation signal transduction and transcriptional regulation influencing key cellular functions.
Pathways
FBXL18 integrates into the Wnt/β-catenin and NF-κB signaling pathways. In the Wnt/β-catenin pathway FBXL18 interacts with β-catenin playing a part in its degradation and therefore influencing cellular decisions regarding proliferation and differentiation. In the context of the NF-κB pathway FBXL18 affects the stability of proteins like IκB which modulates NF-κB transcription factor activity. This connects FBXL18 to proteins such as β-catenin and IκB within these pathways highlighting its influence on these important signaling cascades.
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Target data
Publications (1)
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Bioengineered 13:12030-12044 PubMed35549643
2022
Applications
Unspecified application
Species
Unspecified reactive species
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