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AB67232

Anti-FBXL20 antibody

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(1 Publication)

Rabbit Polyclonal FBXL20 antibody. Suitable for WB and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human FBXL20.

View Alternative Names

FBL2, F-box/LRR-repeat protein 20, F-box and leucine-rich repeat protein 20, F-box/LRR-repeat protein 2-like

1 Images
Western blot - Anti-FBXL20 antibody (AB67232)
  • WB

Unknown

Western blot - Anti-FBXL20 antibody (AB67232)

Lane 1:

Western blot - Anti-FBXL20 antibody (ab67232) at 0.5 µg/mL

Lane 2:

Western blot - Anti-FBXL20 antibody (ab67232) at 1 µg/mL

Lane 1:

A20 (Mouse reticulum sarcoma cell line) whole cell lysate at 15 µg

Lane 2:

A20 cell lysate at 15 µg

Predicted band size: 48 kDa

Observed band size: 44 kDa,48 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

WB

applications

Immunogen

Synthetic Peptide within Human FBXL20. The exact immunogen used to generate this antibody is proprietary information.

Q96IG2

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Complementary Products

Primary Antibodies

AB17018

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Primary Antibodies

AB66978

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Primary Antibodies

AB58416

Anti-E3 SUMO-protein ligase PIAS4/PIASy antibody

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-E3 SUMO-protein ligase PIAS4/PIASy antibody (AB58416)

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Primary Antibodies

AB68807

Anti-GIYD2 antibody

Western blot - Anti-GIYD2 antibody (AB68807)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-1 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FBXL20 also known as F-box and leucine-rich repeat protein 20 functions as part of the SCF (SKP1-cullin-F-box) ubiquitin ligase complex. This protein weighs approximately 45 kDa and plays an important role in protein degradation by facilitating ubiquitination marking proteins for proteasomal degradation. FBXL20 shows expression in various tissues including the brain and heart suggesting its role in multiple physiological processes.
Biological function summary

The protein helps regulate important cellular processes such as cell cycle control and signal transduction. It acts as part of the larger SCF complex where it recognizes and binds specific phosphorylated substrates. Through these interactions FBXL20 maintains cellular homeostasis by targeting key regulatory proteins for degradation impacting overall cellular function.

Pathways

FBXL20 integrates into the cell cycle and Wnt signaling pathways. In the cell cycle pathway it ensures proper progression through different phases by targeting cyclins for degradation. In the Wnt signaling pathway FBXL20 affects the stability of proteins like β-catenin important for proper signal transmission. It interacts with related proteins such as SKP1 and Cullin-1 within these pathways to execute its functions efficiently.

FBXL20 influences the development of cancer and neurodegenerative diseases. Altered FBXL20 function can disrupt regular protein degradation patterns leading to accumulations that contribute to tumorigenesis or neuronal damage. In cancer its interaction with proteins such as p53 can affect tumor suppression. Similarly in neurodegenerative diseases like Alzheimer's disrupted degradation pathways involving FBXL20 may play a role in disease progression.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity).
See full target information FBXL20
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

International journal of stem cells 18:59-71 PubMed39734065

2024

The Effect of Nerve Growth Factor on Cartilage Fibrosis and Hypertrophy during Chondrogenesis Using Induced Pluripotent Stem Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Se In Jung,Si Hwa Choi,Jang-Woon Kim,Jooyoung Lim,Yeri Alice Rim,Ji Hyeon Ju
View all publications
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Product promise

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For full details, please see our Terms & Conditions

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