Anti-FBXL3 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

FBXL3 also known as F-box and leucine-rich repeat protein 3 acts as part of the protein complex responsible for targeted degradation of other proteins. It has a molecular mass of approximately 46 kDa and plays its role mainly in the nucleus. Researchers have found FBXL3 expressed in multiple tissues including the brain indicating its widespread biological importance. This protein forms part of the Skp Cullin F-box containing complex (SCF complex) which functions in regulating the degradation of proteins via ubiquitination.

Biological function summary

FBXL3 participates in the regulation of circadian rhythms controlling the degradation of specific clock proteins like CRY1 and CRY2. These proteins along with FBXL3 form part of the SCF complex. By targeting CRY proteins for degradation FBXL3 influences the stability and timing of the molecular clock. This role underlines FBXL3's importance in maintaining daily physiological rhythms that affect behavior and biologic processes.

Pathways

FBXL3 integrates into the ubiquitin-proteasome system and the circadian clock pathway. Its interaction with CRY1 and CRY2 proteins highlights its role in circadian rhythm regulation. Additionally FBXL3's function in these pathways affects proteins such as PER proteins which are also relevant for the correct functioning of the biological clock. This pathway regulation is essential for synchronization with the day-night cycle.

Associated diseases and disorders

Defects in FBXL3 function associate with circadian rhythm sleep disorders and certain mood disorders like bipolar disorder. Dysregulation of CRY proteins due to improper FBXL3 function can affect sleep-wake cycles and lead to these conditions. Furthermore FBXL3 interactions with proteins like CRY1 indicate potential impacts on disorders that relate to disrupted circadian biology influencing both physiological and psychological health.