Anti-FBXO16 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

FBXO16 also known as F-box only protein 16 is a component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex. It plays a role in targeting proteins for ubiquitination and subsequent proteasomal degradation. The molecular mass of FBXO16 is approximately 45 kDa. This protein is expressed in various tissues with significant levels observed in the brain and reproductive organs. Its expression pattern suggests an involvement in diverse cellular processes depending on tissue type.

Biological function summary

F-box proteins like FBXO16 are important in regulating the stability of specific proteins. FBXO16 is part of the SCF complex which functions as a molecular machinery to control protein turnover by attaching ubiquitin to target proteins. This process marks them for degradation maintaining cellular protein homeostasis. Proper function of such networks is essential for regulating cell cycle growth and response to environmental stimuli among other cellular processes.

Pathways

FBXO16 plays a role in ubiquitin-proteasome pathways. It interacts within pathways that involve protein degradation impacting cellular processes like cell cycle regulation and apoptosis. Additionally FBXO16 interacts with proteins involved in signaling pathways such as those modulating p53 a critical protein for DNA repair and apoptosis. These interactions highlight FBXO16’s impact on maintaining cellular health and responding to cellular stress.

Associated diseases and disorders

FBXO16 links to cancers due to its role in protein degradation pathways that control cell proliferation. Alterations in FBXO16 expression or function can disrupt normal regulatory processes leading to tumor development and progression. Furthermore there is evidence suggesting FBXO16 interacts with proteins such as p53 and beta-catenin which are also implicated in cancer pathways. This connection indicates potential FBXO16 involvement in tumorigenesis and highlights its importance as a target for therapeutic intervention.