AB198865

Anti-FBXO31 antibody - C-terminal

Name: Anti-FBXO31 antibody - C-terminal (ab198865) | Abcam
Brand: Abcam Limited
SKU: AB198865
Price: 525 USD
Availability: InStock

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(2 Publications)

Rabbit Polyclonal FBXO31 antibody. C-terminal. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human FBXO31.

View Alternative Names

FBX14, FBX31, PP2386, FBXO31, F-box only protein 31

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FBXO31 antibody - C-terminal (AB198865)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FBXO31 antibody - C-terminal (AB198865)

Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue labeling FBXO31 with ab198865 at 1/40 dilution.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FBXO31 antibody - C-terminal (AB198865)

Immunohistochemical analysis of paraffin-embedded Human gastric cancer tissue labeling FBXO31 with ab198865 at 1/40 dilution.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human FBXO31. The exact immunogen used to generate this antibody is proprietary information.

Q5XUX0

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol." }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FBXO31 also known as F-box only protein 31 functions as part of the SCF (SKP1-Cullin-F-box) E3 ubiquitin protein ligase complex. It plays a role in marking proteins for proteasomal degradation. The molecular weight of FBXO31 is approximately 73 kDa. Gene expression analysis shows FBXO31 is present in various tissues with notable levels in the brain liver and kidney.

Biological function summary

FBXO31 regulates cell cycle progression and stress response pathways. It forms part of the SCF complex facilitating ubiquitination by recognizing and binding specific substrates. The protein contributes to the regulation of cell cycle checkpoints and is involved in DNA repair processes. This makes FBXO31 important for maintaining genomic stability during cell division and protecting against cellular stress.

Pathways

FBXO31 interacts with mechanisms like the p53 signaling pathway and the ubiquitin-dependent proteolysis pathway. In the p53 signaling pathway FBXO31 targets specific proteins that modulate p53 activity affecting cell cycle arrest and apoptosis. Additionally FBXO31 links to other proteins such as SKP1 and Cullin which are essential components of the SCF complex and participate in substrate ubiquitination.

FBXO31 has associations with cancer particularly breast and liver cancers. FBXO31 levels can influence tumor suppressor functions linking it to the pathogenesis of these cancers. Researchers have observed connections between FBXO31 and p53 mutations which further implicate its role in tumor development and progression. Understanding these associations highlights the potential of FBXO31 as a target for therapeutic strategies in oncology.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor.

See full target information FBXO31

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Aging and disease 15:804-823 PubMed37611899

2023

Aberrantly High FBXO31 Impairs Oocyte Quality in Premature Ovarian Insufficiency.

Applications

Unspecified application

Species

Unspecified reactive species

Feiyan Zhao,Long Yan,Xuehan Zhao,Jiaqi Wu,Ying Fang,Zhimin Xin,Hongmei Wang,Xiaokui Yang

Cell communication and signaling : CCS 18:152 PubMed32943060

2020

CLPTM1L induces estrogen receptor β signaling-mediated radioresistance in non-small cell lung cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Hang Li,Jun Che,Mian Jiang,Ming Cui,Guoxing Feng,Jiali Dong,Shuqin Zhang,Lu Lu,Weili Liu,Saijun Fan

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-FBXO31 antibody - C-terminal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FBXO31 antibody - C-terminal (AB198865)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FBXO31 antibody - C-terminal (AB198865)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (2)

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