Rabbit Polyclonal FBXO38 antibody. Suitable for IHC-P, IP, WB and reacts with Human, Mouse samples. Immunogen corresponding to Synthetic Peptide within Human FBXO38 aa 850-900.
View Alternative Names
SP329, FBXO38, F-box only protein 38
- WB
Unknown
Western blot - Anti-FBXO38 antibody (AB87729)
All lanes:
Western blot - Anti-FBXO38 antibody (ab87729) at 0.1 µg/mL
Lane 1:
Whole cell lysate from HeLa cells at 50 µg
Lane 2:
Whole cell lysate from HeLa cells at 15 µg
Lane 3:
Whole cell lysate from HeLa cells at 5 µg
Lane 4:
Whole cell lysate from NIH3T3 cells at 50 µg
Predicted band size: 134 kDa
Observed band size: 107 kDa,134 kDa
true
Exposure time: 3min
- IHC-P
Unknown
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FBXO38 antibody (AB87729)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human prostate carcinoma (right) and human testicular seminoma (right) tissues labelling F box protein 38 with ab87729 at 1/1000 (1µg/ml). Detection : DAB.
- IP
Unknown
Immunoprecipitation - Anti-FBXO38 antibody (AB87729)
Detection of FBXO38 in Immunoprecipitates of Whole cell lysate from HeLa cells (1 mg for IP, 20% of IP loaded) using ab87729 at 10 μg/mg lysate for IP (Lane 1) and at 1 μg/ml for subsequent Western blot detection. Lane 2 represents control IgG IP. Detection : Chemiluminescence with an exposure time of 30 seconds.
All lanes:
Immunoprecipitation - Anti-FBXO38 antibody (ab87729)
Predicted band size: 134 kDa
false
Reactivity data
Properties and storage information
Form
Purification technique
Storage buffer
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
FBXO38 participates in regulating protein stability and turnover as an integral component of the ubiquitin-proteasome system. As part of the SCF complex FBXO38 works in collaboration with SKP1 CUL1 and other F-box proteins to select target proteins for ubiquitination. Its role in this complex positions it as a critical regulator of cell cycle progression apoptosis and signal transduction pathways. By selecting specific proteins for degradation FBXO38 influences key cellular functions and ensures proper cellular responses to environmental changes.
Pathways
The function of FBXO38 aligns with the regulation of the MAPK/ERK pathway and the NF-kB pathway. These pathways are essential for cell proliferation survival and inflammation responses. In the MAPK/ERK pathway FBXO38 interacts with components to ensure timely degradation of key signaling proteins thereby modulating pathway activity. Furthermore FBXO38’s interaction with proteins like IκBα in the NF-kB pathway helps control the transcriptional activity of NF-kB influencing immunological and stress responses.
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Target data
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