Anti-FBXO40 antibody [EPR15005]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

FBXO40 also known as F-box only protein 40 is a member of the F-box protein family which is characterized by containing an approximately 40 amino acid motif known as the F-box. It has a mass of around 48 kDa. Mechanically FBXO40 functions as part of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex targeting specific proteins for ubiquitination and subsequent proteasomal degradation. This protein embeds itself within skeletal muscle tissue where its expression plays an essential role.

Biological function summary

FBXO40 regulates muscle protein turnover and influences muscle mass maintenance. As part of a ubiquitin ligase complex FBXO40 participates actively in marking proteins for degradation which is essential for cellular homeostasis. The regulation of signaling molecules involved in muscle physiology makes FBXO40 an important player in maintaining muscle integrity and function. The activity of FBXO40 can indirectly affect muscle growth and the adaptation of muscle tissue to various physiological conditions.

Pathways

FBXO40 engages in the ubiquitin-proteasome system which is critical for protein quality control and cellular regulation. It works alongside other proteins like SKP1 in the SCF complex which targets specific proteins for degradation ensuring proper protein balance within the cell. The interaction with pathways involving skeletal muscle differentiation and remodeling highlights its role in the precise regulation of cellular signaling mechanisms important for muscle development and function.

Associated diseases and disorders

Research indicates that FBXO40 may associate with muscular dystrophies characterised by the progressive weakening of muscle mass. It is particularly implicated in the pathology of conditions that affect muscle protein breakdown and synthesis. FBXO40 has also been connected with proteins such as myostatin which inhibit muscle growth suggesting a potential link between disrupted FBXO40 function and muscle-related disorders. The understanding of FBXO40's role could contribute to the development of therapeutic strategies addressing genetic muscle diseases.