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AB153853

Anti-FbxO6 antibody

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(4 Publications)

Rabbit Polyclonal FbxO6 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human FBXO6 aa 1 to C-terminus.

View Alternative Names

FBG2, FBS2, FBX6, FBXO6, F-box only protein 6, F-box protein that recognizes sugar chains 2, F-box/G-domain protein 2

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FbxO6 antibody (AB153853)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FbxO6 antibody (AB153853)

Immunohistochemical analysis of paraffin-embedded Colon using ab153853 antibody at 1/500 dilution

Western blot - Anti-FbxO6 antibody (AB153853)
  • WB

Unknown

Western blot - Anti-FbxO6 antibody (AB153853)

12% SDS PAGE

All lanes:

Western blot - Anti-FbxO6 antibody (ab153853) at 1/500 dilution

All lanes:

293T whole cell lysate at 30 µg

Predicted band size: 34 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human FBXO6 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9NRD1

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p>Alternatively Tris-EDTA buffer (pH8.0) may be used.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to ensure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication.
See full target information FBXO6
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Cancer immunology research 13:1284-1302 PubMed40512146

2025

Tumor Cell-Intrinsic Decr2 Regulates Ferroptosis and Immunotherapy Efficacy.

Applications

Unspecified application

Species

Unspecified reactive species

Shuyin Li,Jason W Shapiro,Hardik Shah,Emily F Higgs,Lishi Xie,Yaopeng Li,Yuanyuan Zha,Jonathan Trujillo,Alexandra Cabanov,Tyler A Jones,Blake Flood,Ken Hatogai,Ruxandra Tonea,Justin Kline,Thomas F Gajewski

Redox biology 58:102544 PubMed36427397

2022

CPT1A promotes anoikis resistance in esophageal squamous cell carcinoma via redox homeostasis.

Applications

Unspecified application

Species

Unspecified reactive species

Tian Tian,Yunxin Lu,Jinfei Lin,Miao Chen,Huijuan Qiu,Wancui Zhu,Haohui Sun,Jinsheng Huang,Han Yang,Wuguo Deng

Journal of orthopaedic translation 29:123-133 PubMed34249610

2021

Role of the miR-133a-5p/FBXO6 axis in the regulation of intervertebral disc degeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Xian-Fa Du,Hai-Tao Cui,He-Hai Pan,Jun Long,Hao-Wen Cui,Shun-Lun Chen,Jian-Ru Wang,Ze-Min Li,Hui Liu,Yong-Can Huang,Hua Wang,Zhao-Min Zheng

FEBS letters 593:1827-1836 PubMed31140586

2019

Fbxo6 confers drug-sensitization to cisplatin via inhibiting the activation of Chk1 in non-small cell lung cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Lin Cai,Jingduo Li,Jing Zhao,Yingxue Guo,Menghua Xie,Xiupeng Zhang,Liang Wang,Hua Tian,Ailin Li,Qingchang Li,Yuan Miao
View all publications
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Product promise

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