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AB170491

Anti-FCAMR antibody [10C4]

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(1 Publication)

Mouse Monoclonal FCAMR antibody. Suitable for IHC-P, ICC/IF, Flow Cyt, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human FCAMR.

View Alternative Names

CD351, FKSG87, FCAMR, High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor, Fc alpha/mu receptor

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

10C4

Isotype

IgG2a

Carrier free

No

Reacts with

Human

Applications

IHC-P, Flow Cyt, WB, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human FCAMR. The exact immunogen used to generate this antibody is proprietary information.

Q8WWV6

Specificity

ab170491 recognizes an epitope between the EC1 and EC2 domain of Human FCAMR.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>", "FlowCyt-species-checked": "guaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The FCAMR (Fc receptor IgA IgM high affinity) is a protein that functions as a receptor for immunoglobulins IgA and IgM. It is also known by the alternate name Fcalpha/muR. FCAMR is expressed on various cells such as immune cells including B cells and macrophages and it has a molecular mass of approximately 60 kilodaltons. The receptor facilitates the binding and endocytosis of IgA and IgM primarily affecting the clearance of immune complexes and pathogens.
Biological function summary

FCAMR plays a role in the immune response by acting as part of the host defense system. It binds to IgA and IgM which are essential antibodies in mucosal immunity and systemic immune response respectively. FCAMR interacts with immune complexes possibly forming part of a larger receptor complex involved in immune signaling and regulation. Through this action FCAMR contributes to maintaining immune system balance and preventing excessive inflammation.

Pathways

FCAMR is implicated in immune regulation processes including the mucosal immune response and phagocytosis pathway. It participates alongside proteins like polymeric immunoglobulin receptor (pIgR) which also interacts with IgA. This receptor is important for the immune surveillance and clearance of antigens at mucosal surfaces. FCAMR's functional role in these pathways ensures efficient antigen removal and contributes to the body's defense mechanisms against pathogens.

FCAMR associates with certain autoimmune conditions and infections such as IgA nephropathy and bacterial infections. In IgA nephropathy the receptor's interaction with IgA deposits may influence the disease's progression. Moreover FCAMR's role in bacterial infection is linked to its capacity to clear immune complexes and pathogens working in coordination with other proteins like the complement system to mediate immune defense. Understanding FCAMR's involvement in these conditions helps to reveal potential therapeutic targets for treatment.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Functions as a receptor for the Fc fragment of IgA and IgM. Binds IgA and IgM with high affinity and mediates their endocytosis. May function in the immune response to microbes mediated by IgA and IgM.
See full target information FCAMR
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Diseases (Basel, Switzerland) 11: PubMed37873783

2023

Systematic Evaluation of the Distribution of Immune Cells following Subcutaneous Administration of Haemophilus Influenzae Type B Vaccine to Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Yao He,Yuxiu Zhao,Hongyang Liang,Xue Wang,Haoyue Lan,Dongyang Tian,Yan Li,Hui Wang
View all publications
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Product promise

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