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AB121202

Anti-FCGBP antibody

0

(1 Review)

|

(5 Publications)

Rabbit Polyclonal FCGBP antibody. Suitable for IHC-P and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human IgGFc-binding protein aa 250-450.

View Alternative Names

IgGFc-binding protein, Fcgamma-binding protein antigen, FcgammaBP, FCGBP

4 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FCGBP antibody (AB121202)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FCGBP antibody (AB121202)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human liver tissue labelling FCGBP with ab121202 at 1/200 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FCGBP antibody (AB121202)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FCGBP antibody (AB121202)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human small intestine tissue labelling FCGBP with ab121202 at 1/200 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FCGBP antibody (AB121202)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FCGBP antibody (AB121202)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human testis tissue labelling FCGBP with ab121202 at 1/200 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FCGBP antibody (AB121202)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FCGBP antibody (AB121202)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human kidney tissue labelling FCGBP with ab121202 at 1/200 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human IgGFc-binding protein aa 250-450. The exact immunogen used to generate this antibody is proprietary information.

Q9Y6R7

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FCGBP also known as IgGFc-binding protein is a large glycoprotein with an approximate mass of 540 kDa. It plays a mechanical role in binding immunoglobulin G Fc fragments which suggests possible involvement in the immune system. Researchers have observed its expression in various mucosal tissues including the intestinal tract and the airway epithelium. There it may interact with mucosal antibodies and contribute to the formation of protective barriers.
Biological function summary

The function of FCGBP involves interactions within the mucosal immune response. It forms complexes with mucins such as MUC2 facilitating the gel-like structure of mucus essential for barrier function. The protein helps in protecting tissues from pathogens and environmental insults through its role in stabilizing the mucus layer. Such interactions highlight its significance in maintaining mucosal immunity and homeostasis especially in environments exposed to external elements.

Pathways

FCGBP is essential in both the innate and adaptive immune pathways. In the mucosal immunity pathway it collaborates with mucins to regulate pathogen access to epithelial surfaces. Additionally its interactions with proteins like IgG provide a link to the immune system's antibody-mediated processes. Through these pathways FCGBP ensures the protection of mucosal surfaces from pathogenic invasion and supports immune surveillance.

FCGBP shows associations with conditions like inflammatory bowel disease (IBD) and cystic fibrosis. In IBD altered mucosal barrier function implicates FCGBP due to its role in mucus integrity. MUC2 abnormalities often accompany these diseases and show how disrupted interactions with FCGBP contribute to mucosal inflammation and barrier dysfunction. In cystic fibrosis faulty mucus barriers highlight the protein's importance in respiratory health connecting it to pulmonary conditions where disrupted mucus properties are common.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May be involved in the maintenance of the mucosal structure as a gel-like component of the mucosa.
See full target information IgGFc-binding protein
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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Aging 16:7889-7901 PubMed38709264

2024

Predictive value of FCGBP expression for treatment response and survival in rectal cancer patients undergoing chemoradiotherapy.

Applications

Unspecified application

Species

Unspecified reactive species

Yu-Ting Su,Chung-Hsing Chen,Jui-Wen Kang,Hsin-Yu Kuo,Ching-Chieh Yang,Yu-Feng Tian,Cheng-Fa Yeh,Chia-Lin Chou,Shang-Hung Chen

Communications biology 6:85 PubMed36690709

2023

Single-cell profiling reveals differences between human classical adenocarcinoma and mucinous adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Fang-Jie Hu,Ying-Jie Li,Li Zhang,Deng-Bo Ji,Xin-Zhi Liu,Yong-Jiu Chen,Lin Wang,Ai-Wen Wu

Innate immunity 27:423-436 PubMed34521229

2021

Neglected roles of IgG Fc-binding protein secreted from airway mucin-producing cells in protecting against SARS-CoV-2 infection.

Applications

Unspecified application

Species

Unspecified reactive species

Kensuke Kobayashi,Mitsuhiro Tachibana,Yutaka Tsutsumi

Aging 13:7416-7429 PubMed33686968

2021

A bioinformatic analysis: the overexpression and clinical significance of FCGBP in ovarian cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Kai Wang,Chenan Guan,Xianwen Shang,Xiang Ying,Shuangshuang Mei,Hanxiao Zhu,Liang Xia,Zeying Chai

Journal of the American Heart Association 6: PubMed29191809

2017

Molecular Fingerprint for Terminal Abdominal Aortic Aneurysm Disease.

Applications

Unspecified application

Species

Unspecified reactive species

Gabor Gäbel,Bernd H Northoff,Irina Weinzierl,Stefan Ludwig,Irene Hinterseher,Wolfgang Wilfert,Daniel Teupser,Stefan A Doderer,Hendrik Bergert,Frank Schönleben,Jan H N Lindeman,Lesca M Holdt
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
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