AB217146

Anti-FCGBP antibody

Name: Anti-FCGBP antibody (ab217146) | Abcam
Brand: Abcam Limited
SKU: AB217146
Price: 525 USD
Availability: InStock

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(2 Publications)

Rabbit Polyclonal Fcgbp antibody. Suitable for IHC-P and reacts with Mouse samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human IgGFc-binding protein aa 450-550 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

FC(GAMMA)BP, FCGBP_HUMAN, Fc fragment of IgG binding protein, Fcgamma-binding protein antigen, FcgammaBP, Human Fc gamma BP, IgGFc-binding protein

1 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FCGBP antibody (AB217146)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FCGBP antibody (AB217146)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded mouse intestine tissue labeling FCGBP with ab217146 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human IgGFc-binding protein aa 450-550 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q9Y6R7

Specificity

There is a chance that this protein will cross-react with Otogelin based on a 61% sequence similarity.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FCGBP also known as IgGFc-binding protein is a large glycoprotein with an approximate mass of 540 kDa. It plays a mechanical role in binding immunoglobulin G Fc fragments which suggests possible involvement in the immune system. Researchers have observed its expression in various mucosal tissues including the intestinal tract and the airway epithelium. There it may interact with mucosal antibodies and contribute to the formation of protective barriers.

Biological function summary

The function of FCGBP involves interactions within the mucosal immune response. It forms complexes with mucins such as MUC2 facilitating the gel-like structure of mucus essential for barrier function. The protein helps in protecting tissues from pathogens and environmental insults through its role in stabilizing the mucus layer. Such interactions highlight its significance in maintaining mucosal immunity and homeostasis especially in environments exposed to external elements.

Pathways

FCGBP is essential in both the innate and adaptive immune pathways. In the mucosal immunity pathway it collaborates with mucins to regulate pathogen access to epithelial surfaces. Additionally its interactions with proteins like IgG provide a link to the immune system's antibody-mediated processes. Through these pathways FCGBP ensures the protection of mucosal surfaces from pathogenic invasion and supports immune surveillance.

FCGBP shows associations with conditions like inflammatory bowel disease (IBD) and cystic fibrosis. In IBD altered mucosal barrier function implicates FCGBP due to its role in mucus integrity. MUC2 abnormalities often accompany these diseases and show how disrupted interactions with FCGBP contribute to mucosal inflammation and barrier dysfunction. In cystic fibrosis faulty mucus barriers highlight the protein's importance in respiratory health connecting it to pulmonary conditions where disrupted mucus properties are common.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

See full target information Fcgbp

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Metabolites 15: PubMed39997701

2025

Hypoxia Dependent Inhibition of Glioblastoma Cell Proliferation, Invasion, and Metabolism by the Choline-Kinase Inhibitor JAS239.

Applications

Unspecified application

Species

Unspecified reactive species

Claire Louise Kelly,Martyna Wydrzynska,Marie M Phelan,Sofya Osharovich,Edward J Delikatny,Violaine Sée,Harish Poptani

Oncology letters 22:526 PubMed34055091

2021

Prognostic and immunological roles of Fc fragment of IgG binding protein in colorectal cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Qunchuan Zhuang,Aling Shen,Liya Liu,Meizhu Wu,Zhiqing Shen,Huixin Liu,Ying Cheng,Xiaoying Lin,Xiangyan Wu,Wei Lin,Jiapeng Li,Yuying Han,Xiaoping Chen,Qi Chen,Jun Peng

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-FCGBP antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FCGBP antibody (AB217146)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Specificity

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (2)

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