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Rabbit Polyclonal FCGRT/FCRN antibody. Extracellular domain. Suitable for WB and reacts with Mouse, Human samples. Cited in 6 publications. Immunogen corresponding to Recombinant Fragment Protein within Human FCGRT aa 1-300.

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Images

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7.4
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Recombinant Fragment Protein within Human FCGRT aa 1-300. The exact immunogen used to generate this antibody is proprietary information. Database link P55899
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Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WBIHC-PICC/IF
Human
Tested
Not recommended
Not recommended
Mouse
Tested
Not recommended
Not recommended
Cynomolgus monkey
Predicted
Not recommended
Not recommended

Tested
Tested

Species

Mouse

Dilution info

1/500 - 1/2000

Notes

-

Species

Human

Dilution info

1/500 - 1/2000

Notes

-

Predicted
Predicted

Species

Cynomolgus monkey

Dilution info

-

Notes

-

Not recommended
Not recommended

Species

Human, Mouse, Cynomolgus monkey

Dilution info

-

Notes

-

Not recommended
Not recommended

Species

Human, Mouse, Cynomolgus monkey

Dilution info

-

Notes

-

Target data

Function

Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk (PubMed:7964511, PubMed:10933786). IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation (PubMed:10998088). In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB (PubMed:24469444, PubMed:28330995).(Microbial infection) Acts as an uncoating receptor for a panel of echoviruses including Echovirus 5, 6, 7, 9, 11, 13, 25 and 29.

Alternative names

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Rabbit Polyclonal FCGRT/FCRN antibody. Extracellular domain. Suitable for WB and reacts with Mouse, Human samples. Cited in 6 publications. Immunogen corresponding to Recombinant Fragment Protein within Human FCGRT aa 1-300.

Alternative names

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Recombinant Fragment Protein within Human FCGRT aa 1-300. The exact immunogen used to generate this antibody is proprietary information. Database link P55899
Purification technique

Affinity purification Protein G

Concentration
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Purification notes

>95%

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

Biological function summary

FCGRT/FCRN is involved in the transportation and recycling of IgG antibodies. It forms a complex with beta-2 microglobulin that contributes to its function. This complex allows IgG antibodies to traverse cellular barriers such as epithelial cells without being digested. This protein is important in maintaining humoral immunity by regulating IgG levels in the bloodstream and similar processes can be observed in mouse FCRN and cynomolgus monkey milk indicating a conserved mechanism across species.

Activity summary

The protein FCGRT also known as FCRN or FcRn has a significant role in the immune system by binding to the Fc region of immunoglobulin G (IgG). This binding prolongs the half-life of IgG by preventing its lysosomal degradation. The molecular mass of the FCGRT protein is roughly 52 kDa. It is prominently expressed in epithelial and endothelial cells across several tissues including the placenta and liver ensuring IgG stability in circulation.

Pathways

FCGRT/FCRN plays a part in the neonatal Fc receptor pathway. This pathway influences IgG homeostasis and impacts antigen presentation to T cells. By doing so it affects immune surveillance and immune tolerance mechanisms. The pathway involves interactions with related proteins such as albumin which also binds to FCRN for extending its half-life in serum.

Associated diseases and disorders

Disruptions in FCGRT/FCRN functionality relate to autoimmune conditions and inflammatory diseases. Conditions such as lupus and myasthenia gravis show altered IgG recycling or transportation implicating FCRN in their pathology. Accordingly researchers have explored FCRN inhibitors as potential therapeutic interventions. These inhibitors aim to modulate the interaction between FCRN and IgG therefore impacting the disease progression linked to these disorders.

Product promise

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In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

2 product images

  • Western blot - Anti-FCGRT/FCRN antibody - Extracellular domain (ab193148), expandable thumbnail

    Western blot - Anti-FCGRT/FCRN antibody - Extracellular domain (ab193148)

    All lanes: Western blot - Anti-FCGRT/FCRN antibody - Extracellular domain (AB193148) at 2 µg

    Lane 1: HepG2 whole cell lysate

    Lane 2: Mouse liver tissue

    Lane 3: Mouse spleen tissue

    Lane 4: A549 whole cell lysate

    Secondary

    All lanes: Goat polyclonal to rabbit IgG at 1/1000 dilution

    Predicted band size: 40 kDa

    Observed band size: 40 kDa

  • Western blot - Anti-FCGRT/FCRN antibody - Extracellular domain (ab193148), expandable thumbnail

    Western blot - Anti-FCGRT/FCRN antibody - Extracellular domain (ab193148)

    All lanes: Western blot - Anti-FCGRT/FCRN antibody - Extracellular domain (AB193148) at 5.3 µg/mL

    Lane 1: Mouse liver tissue lysate

    Lane 2: Mouse kidney tissue lysate

    Secondary

    All lanes: Polyclonal goat anti-rabbit IgG at 1/10000 dilution

    Predicted band size: 40 kDa

    Observed band size: 39 kDa

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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