Rabbit Polyclonal FCGRT/FCRN antibody. Extracellular domain. Suitable for WB and reacts with Mouse, Human samples. Cited in 6 publications. Immunogen corresponding to Recombinant Fragment Protein within Human FCGRT aa 1-300.
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Publications
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- iScience 26:1076482023Antibody attributes, Fc receptor expression, gestation and maternal SARS-CoV-2 infection modulate HSV IgG placental transfer.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAakash Mahant Mahant,Fatima Estrada Trejo,Jennifer T Aguilan,Simone Sidoli,Sallie R Permar,Betsy C HeroldPubMed 37670782
- European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 162:99-1042021The potential of porcine ex vivo platform for intestinal permeability screening of FcRn-targeted drugs.Applications:Unspecified applicationReactive species:Unspecified reactive speciesCláudia Azevedo,Jan Terje Andersen,Giovanni Traverso,Bruno SarmentoPubMed 33771621
- Cell 184:628-642.e102021Compromised SARS-CoV-2-specific placental antibody transfer.Applications:Unspecified applicationReactive species:Unspecified reactive speciesCaroline Atyeo,Krista M Pullen,Evan A Bordt,Stephanie Fischinger,John Burke,Ashlin Michell,Matthew D Slein,Carolin Loos,Lydia L Shook,Adeline A Boatin,Laura J Yockey,David Pepin,Marie-Charlotte Meinsohn,Ngoc Minh Phuong Nguyen,Maeva Chauvin,Drucilla Roberts,Ilona T Goldfarb,Juan D Matute,Kaitlyn E James,Lael M Yonker,Lisa M Bebell,Anjali J Kaimal,Kathryn J Gray,Douglas Lauffenburger,Andrea G Edlow,Galit AlterPubMed 33476549
- Journal of virology 94:2020Early Entry Events in Echovirus 30 Infection.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHelena Vandesande et. al.PubMed 32295914
- Scientific reports 9:86742019Contribution of DNA methylation to the expression of FCGRT in human liver and myocardium.Applications:Unspecified applicationReactive species:Unspecified reactive speciesR B Cejas et. al.PubMed 31209240
- Cell 177:1553-1565.e162019Human Neonatal Fc Receptor Is the Cellular Uncoating Receptor for Enterovirus B.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXin Zhao et. al.PubMed 31104841
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human FCGRT aa 1-300. The exact immunogen used to generate this antibody is proprietary information. Database link P55899
Reactivity data
Select an application| WB | IHC-P | ICC/IF | |
|---|---|---|---|
| Human | Tested | Not recommended | Not recommended |
| Mouse | Tested | Not recommended | Not recommended |
| Cynomolgus monkey | Predicted | Not recommended | Not recommended |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 1/500 - 1/2000 | Notes - |
Species Human | Dilution info 1/500 - 1/2000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Cynomolgus monkey | Dilution info - | Notes - |
IHC-P
Not recommendedNot recommended
| Species | Dilution info | Notes |
|---|---|---|
Species Human, Mouse, Cynomolgus monkey | Dilution info - | Notes - |
ICC/IF
Not recommendedNot recommended
| Species | Dilution info | Notes |
|---|---|---|
Species Human, Mouse, Cynomolgus monkey | Dilution info - | Notes - |
Associated Products
Select an associated product type
6 products for Alternative Product
Target data
Function
Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk (PubMed:10933786, PubMed:7964511). IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation (PubMed:10998088). In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB (PubMed:24469444, PubMed:28330995). (Microbial infection) Acts as an uncoating receptor for a panel of echoviruses including Echovirus 5, 6, 7, 9, 11, 13, 25 and 29.
Alternative names
FCRN, FCGRT, IgG receptor FcRn large subunit p51, FcRn, IgG Fc fragment receptor transporter alpha chain, Neonatal Fc receptor
Recommended products
Rabbit Polyclonal FCGRT/FCRN antibody. Extracellular domain. Suitable for WB and reacts with Mouse, Human samples. Cited in 6 publications. Immunogen corresponding to Recombinant Fragment Protein within Human FCGRT aa 1-300.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human FCGRT aa 1-300. The exact immunogen used to generate this antibody is proprietary information. Database link P55899
- Purification technique
- Affinity purification Protein G
- Concentration
- Purification notes
>95%
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The protein FCGRT also known as FCRN or FcRn has a significant role in the immune system by binding to the Fc region of immunoglobulin G (IgG). This binding prolongs the half-life of IgG by preventing its lysosomal degradation. The molecular mass of the FCGRT protein is roughly 52 kDa. It is prominently expressed in epithelial and endothelial cells across several tissues including the placenta and liver ensuring IgG stability in circulation.
- Biological function summary
FCGRT/FCRN is involved in the transportation and recycling of IgG antibodies. It forms a complex with beta-2 microglobulin that contributes to its function. This complex allows IgG antibodies to traverse cellular barriers such as epithelial cells without being digested. This protein is important in maintaining humoral immunity by regulating IgG levels in the bloodstream and similar processes can be observed in mouse FCRN and cynomolgus monkey milk indicating a conserved mechanism across species.
- Pathways
FCGRT/FCRN plays a part in the neonatal Fc receptor pathway. This pathway influences IgG homeostasis and impacts antigen presentation to T cells. By doing so it affects immune surveillance and immune tolerance mechanisms. The pathway involves interactions with related proteins such as albumin which also binds to FCRN for extending its half-life in serum.
- Associated diseases and disorders
Disruptions in FCGRT/FCRN functionality relate to autoimmune conditions and inflammatory diseases. Conditions such as lupus and myasthenia gravis show altered IgG recycling or transportation implicating FCRN in their pathology. Accordingly researchers have explored FCRN inhibitors as potential therapeutic interventions. These inhibitors aim to modulate the interaction between FCRN and IgG therefore impacting the disease progression linked to these disorders.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Western blot - Anti-FCGRT/FCRN antibody - Extracellular domain (ab193148)
All lanes: Western blot - Anti-FCGRT/FCRN antibody - Extracellular domain (ab193148) at 2 µg
Lane 1: HepG2 whole cell lysate
Lane 2: Mouse liver tissue
Lane 3: Mouse spleen tissue
Lane 4: A549 whole cell lysate
SecondaryAll lanes: Goat polyclonal to rabbit IgG at 1/1000 dilution
Predicted band size: 40 kDa
Observed band size: 40 kDa
Western blot - Anti-FCGRT/FCRN antibody - Extracellular domain (ab193148)
All lanes: Western blot - Anti-FCGRT/FCRN antibody - Extracellular domain (ab193148) at 5.3 µg/mL
Lane 1: Mouse liver tissue lysate
Lane 2: Mouse kidney tissue lysate
SecondaryAll lanes: Polyclonal goat anti-rabbit IgG at 1/10000 dilution
Predicted band size: 40 kDa
Observed band size: 39 kDa
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