AB193148

Anti-FCGRT/FCRN antibody - Extracellular domain

Name: Anti-FCGRT/FCRN antibody - Extracellular domain (ab193148) | Abcam
Brand: Abcam Limited
SKU: AB193148

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(9 Publications)

Rabbit Polyclonal FCGRT/FCRN antibody. Extracellular domain. Suitable for WB and reacts with Mouse, Human samples. Cited in 9 publications. Immunogen corresponding to Recombinant Fragment Protein within Human FCGRT aa 1-300.

View Alternative Names

FCRN, FCGRT, IgG receptor FcRn large subunit p51, FcRn, IgG Fc fragment receptor transporter alpha chain, Neonatal Fc receptor

2 Images

Supplier Data

Western blot - Anti-FCGRT/FCRN antibody - Extracellular domain (AB193148)

All lanes:

Western blot - Anti-FCGRT/FCRN antibody - Extracellular domain (ab193148) at 2 µg

Lane 1:

HepG2 whole cell lysate

Lane 2:

Mouse liver tissue

Lane 3:

Mouse spleen tissue

Lane 4:

A549 whole cell lysate

Secondary

All lanes:

Goat polyclonal to rabbit IgG at 1/1000 dilution

Predicted band size: 40 kDa

Observed band size: 40 kDa

false

Supplier Data

Western blot - Anti-FCGRT/FCRN antibody - Extracellular domain (AB193148)

All lanes:

Western blot - Anti-FCGRT/FCRN antibody - Extracellular domain (ab193148) at 5.3 µg/mL

Lane 1:

Mouse liver tissue lysate

Lane 2:

Mouse kidney tissue lysate

Secondary

All lanes:

Polyclonal goat anti-rabbit IgG at 1/10000 dilution

Predicted band size: 40 kDa

Observed band size: 39 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Human

Applications

applications

Immunogen

Recombinant Fragment Protein within Human FCGRT aa 1-300. The exact immunogen used to generate this antibody is proprietary information.

P55899

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cynomolgus monkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein G

Purification notes

>95%

Storage buffer

pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protein FCGRT also known as FCRN or FcRn has a significant role in the immune system by binding to the Fc region of immunoglobulin G (IgG). This binding prolongs the half-life of IgG by preventing its lysosomal degradation. The molecular mass of the FCGRT protein is roughly 52 kDa. It is prominently expressed in epithelial and endothelial cells across several tissues including the placenta and liver ensuring IgG stability in circulation.

Biological function summary

FCGRT/FCRN is involved in the transportation and recycling of IgG antibodies. It forms a complex with beta-2 microglobulin that contributes to its function. This complex allows IgG antibodies to traverse cellular barriers such as epithelial cells without being digested. This protein is important in maintaining humoral immunity by regulating IgG levels in the bloodstream and similar processes can be observed in mouse FCRN and cynomolgus monkey milk indicating a conserved mechanism across species.

Pathways

FCGRT/FCRN plays a part in the neonatal Fc receptor pathway. This pathway influences IgG homeostasis and impacts antigen presentation to T cells. By doing so it affects immune surveillance and immune tolerance mechanisms. The pathway involves interactions with related proteins such as albumin which also binds to FCRN for extending its half-life in serum.

Disruptions in FCGRT/FCRN functionality relate to autoimmune conditions and inflammatory diseases. Conditions such as lupus and myasthenia gravis show altered IgG recycling or transportation implicating FCRN in their pathology. Accordingly researchers have explored FCRN inhibitors as potential therapeutic interventions. These inhibitors aim to modulate the interaction between FCRN and IgG therefore impacting the disease progression linked to these disorders.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk (PubMed : 10933786, PubMed : 7964511). IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation (PubMed : 10998088). In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB (PubMed : 24469444, PubMed : 28330995).. (Microbial infection) Acts as an uncoating receptor for a panel of echoviruses including Echovirus 5, 6, 7, 9, 11, 13, 25 and 29.

See full target information FCGRT

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Publications (9)

Recent publications for all applications. Explore the full list and refine your search

Science advances 11:eady6386 PubMed40991712

2025

Site-specific adaptive nanovesicles for oral insulin delivery.

Applications

Unspecified application

Species

Unspecified reactive species

Bozhang Xia,Fengfei Xu,Junge Chen,Shaobo Shan,Jiuheng Shen,Yuxuan Zhang,Jinjin Wang,Ziran Zhou,Weilun Sun,Yaru Jia,Ya-Li Zhang,Jie Zhong,Gang Zhang,Yichen Wan,Zhongbo Hu,Wenlin An,Yubo Fan,Massimo Bottini,Jinqiang Wang,Xing-Jie Liang

Nature communications 15:6726 PubMed39112502

2024

The neonatal Fc receptor (FcRn) is a pan-arterivirus receptor.

Applications

Unspecified application

Species

Unspecified reactive species

Teressa M Shaw,Devra Huey,Makky Mousa-Makky,Jared Compaleo,Kylie Nennig,Aadit P Shah,Fei Jiang,Xueer Qiu,Devon Klipsic,Raymond R R Rowland,Igor I Slukvin,Meagan E Sullender,Megan T Baldridge,Haichang Li,Cody J Warren,Adam L Bailey

Cell metabolism 36:793-807.e5 PubMed38378001

2024

IgG is an aging factor that drives adipose tissue fibrosis and metabolic decline.

Applications

Unspecified application

Species

Unspecified reactive species

Lexiang Yu,Qianfen Wan,Qiongming Liu,Yong Fan,Qiuzhong Zhou,Alicja A Skowronski,Summer Wang,Zhengping Shao,Chen-Yu Liao,Lei Ding,Brian K Kennedy,Shan Zha,Jianwen Que,Charles A LeDuc,Lei Sun,Liheng Wang,Li Qiang

iScience 26:107648 PubMed37670782

2023

Antibody attributes, Fc receptor expression, gestation and maternal SARS-CoV-2 infection modulate HSV IgG placental transfer.

Applications

Unspecified application

Species

Unspecified reactive species

Aakash Mahant Mahant,Fatima Estrada Trejo,Jennifer T Aguilan,Simone Sidoli,Sallie R Permar,Betsy C Herold

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 162:99-104 PubMed33771621

2021

The potential of porcine ex vivo platform for intestinal permeability screening of FcRn-targeted drugs.

Applications

Unspecified application

Species

Unspecified reactive species

Cláudia Azevedo,Jan Terje Andersen,Giovanni Traverso,Bruno Sarmento

Cell 184:628-642.e10 PubMed33476549

2021

Compromised SARS-CoV-2-specific placental antibody transfer.

Applications

Unspecified application

Species

Unspecified reactive species

Caroline Atyeo,Krista M Pullen,Evan A Bordt,Stephanie Fischinger,John Burke,Ashlin Michell,Matthew D Slein,Carolin Loos,Lydia L Shook,Adeline A Boatin,Laura J Yockey,David Pepin,Marie-Charlotte Meinsohn,Ngoc Minh Phuong Nguyen,Maeva Chauvin,Drucilla Roberts,Ilona T Goldfarb,Juan D Matute,Kaitlyn E James,Lael M Yonker,Lisa M Bebell,Anjali J Kaimal,Kathryn J Gray,Douglas Lauffenburger,Andrea G Edlow,Galit Alter

Journal of virology 94: PubMed32295914

2020

Early Entry Events in Echovirus 30 Infection.

Applications

Unspecified application

Species

Unspecified reactive species

Helena Vandesande,Mira Laajala,Tino Kantoluoto,Visa Ruokolainen,A Michael Lindberg,Varpu Marjomäki

Scientific reports 9:8674 PubMed31209240

2019

Contribution of DNA methylation to the expression of FCGRT in human liver and myocardium.

Applications

Unspecified application

Species

Unspecified reactive species

R B Cejas,D C Ferguson,A Quiñones-Lombraña,J E Bard,J G Blanco

Cell 177:1553-1565.e16 PubMed31104841

2019

Human Neonatal Fc Receptor Is the Cellular Uncoating Receptor for Enterovirus B.

Applications

Unspecified application

Species

Unspecified reactive species

Xin Zhao,Guigen Zhang,Sheng Liu,Xiangpeng Chen,Ruchao Peng,Lianpan Dai,Xiao Qu,Shihua Li,Hao Song,Zhengrong Gao,Pengfei Yuan,Zhiheng Liu,Changyao Li,Zifang Shang,Yan Li,Meifan Zhang,Jianxun Qi,Han Wang,Ning Du,Yan Wu,Yuhai Bi,Shan Gao,Yi Shi,Jinghua Yan,Yong Zhang,Zhengde Xie,Wensheng Wei,George F Gao

View all publications

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Product promise

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Anti-FCGRT/FCRN antibody - Extracellular domain

Western blot - Anti-FCGRT/FCRN antibody - Extracellular domain (AB193148)

Western blot - Anti-FCGRT/FCRN antibody - Extracellular domain (AB193148)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Alternative Products

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Complementary Products

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (9)

Product promise