Rabbit Polyclonal FDCSP antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human FDCSP aa 1 to C-terminus.
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Publications
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- Cell 175:372-386.e172018Structural Remodeling of the Human Colonic Mesenchyme in Inflammatory Bowel Disease.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJames Kinchen et. al.PubMed 30270042
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human FDCSP aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q8NFU4
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/50.00000 - 1/200.00000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Target data
Function
Can bind to the surface of B-lymphoma cells, but not T-lymphoma cells, consistent with a function as a secreted mediator acting upon B-cells.
Alternative names
C4orf7, UNQ733/PRO1419, FDCSP, Follicular dendritic cell secreted peptide, FDC secreted protein, FDC-SP
Recommended products
Rabbit Polyclonal FDCSP antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human FDCSP aa 1 to C-terminus.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human FDCSP aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q8NFU4
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The protein FDCSP known as Follicular Dendritic Cell Secreted Protein possesses a molecular mass of approximately 8.6 kDa. Researchers find FDCSP mainly expressed in follicular dendritic cells within lymphoid tissues. This protein is small but it holds significant importance in the immune system's architecture. Due to its precise expression pattern FDCSP serves as a useful marker in studies of lymphoid structures and functions.
- Biological function summary
FDCSP plays an important role in the organization of lymphoid follicles and the maintenance of the lymph node microenvironment. It associates with the extracellular matrix supporting communication between dendritic cells and other immune cells. Although not part of a large complex FDCSP influences the network surrounding follicular dendritic cells. This role aids in antigen presentation and lymphocyte activation key elements in the adaptive immune response.
- Pathways
FDCSP connects closely with immune response pathways particularly those regulating antigen presentation and lymphocyte activation. It interacts indirectly with proteins involved in the complement system such as C3 and with receptors on B-lymphocytes. This interaction aids in creating a robust immune response by enhancing antigen presentation and promoting B cell maturation within germinal centers.
- Associated diseases and disorders
FDCSP draws attention because of its involvement in immune-related conditions like autoimmune diseases and lymphomas. Its expression levels may change in diseases such as follicular lymphoma impacting the disease progression. Connections to other proteins such as BAFF (B-cell activating factor) highlight FDCSP's role in B-cell related disorders. Understanding FDCSP's behavior in these contexts helps to shed light on its potential as a diagnostic or therapeutic target.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FDCSP antibody (ab121420)
Immunohistochemical analysis of human tonsil and skeletal muscle tissue labeling FDCSP with ab121420 at 1/50 dilution.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FDCSP antibody (ab121420)
Immunohistochemical analysis of human salivary gland labeling FDCSP with ab121420 at 1/50 dilution. Moderate cytoplasmic positivity in a subset of glandular cells.
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