AB153805

Anti-FDPS/FPS antibody

Name: Anti-FDPS/FPS antibody (ab153805) | Abcam
Brand: Abcam Limited
SKU: AB153805

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(10 Publications)

Rabbit Polyclonal FDPS/FPS antibody. Suitable for WB, ICC/IF, IHC-P and reacts with Human, Mouse samples. Cited in 10 publications. Immunogen corresponding to Recombinant Fragment Protein within Human FDPS aa 1-400.

View Alternative Names

FPS, KIAA1293, FDPS, Farnesyl pyrophosphate synthase, FPP synthase, Dimethylallyltranstransferase, Farnesyl diphosphate synthase, Geranyltranstransferase

2 Images

Supplier Data

Western blot - Anti-FDPS/FPS antibody (AB153805)

Samples were separated by 10% SDS-PAGE. Corresponding RNA expression data for the same cell lines are based on Human Protein Atlas program.

All lanes:

Western blot - Anti-FDPS/FPS antibody (ab153805) at 1/3000 dilution

Lane 1:

HepG2 whole cell extracts at 30 µg

Lane 2:

U87-MG whole cell extracts at 30 µg

Secondary

All lanes:

HRP-conjugated anti-rabbit IgG antibody

Predicted band size: 48 kDa

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Unknown

Western blot - Anti-FDPS/FPS antibody (AB153805)

10% SDS PAGE

All lanes:

Western blot - Anti-FDPS/FPS antibody (ab153805) at 1/3000 dilution

All lanes:

Mouse brain whole cell lysate at 50 µg

Predicted band size: 48 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Human

Applications

WB, IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human FDPS aa 1-400. The exact immunogen used to generate this antibody is proprietary information.

P14324

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "1/100 - 1/1000", "ICCIF-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "Perform heat mediated antigen retrieval before commencing with IHC staining protocol using 10mM Citrate buffer (pH6.0) or Tris-EDTA buffer (pH8.0)." }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7 Preservative: 0.025% Proclin 300 Constituents: PBS, 20% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Farnesyl diphosphate synthase (FDPS) also known as farnesyl pyrophosphate synthase (FPS) is an important enzyme that catalyzes the synthesis of farnesyl diphosphate (FPP) from isopentenyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP). This enzyme plays an important role in the mevalonate pathway which is essential for the biosynthesis of sterols including cholesterol and other isoprenoids. FDPS is a protein with a molecular mass of approximately 42 kDa. Its expression occurs in various tissues with significant levels in liver brain and bone where it contributes to different cellular metabolic processes.

Biological function summary

Farnesyl diphosphate synthase facilitates the production of FPP a common precursor for the synthesis of isoprenoid compounds such as cholesterol ubiquinones and dolichol. FDPS does not form a complex but works in coordination with other enzymes in the mevalonate pathway. Its activity supports numerous cellular functions including membrane assembly protein prenylation and cell signaling. The enzyme’s role is important for normal cellular growth and development influencing processes like cell differentiation and proliferation.

Pathways

FDPS plays a significant role in the cholesterol biosynthesis and protein prenylation pathways. These pathways are critical for cellular homeostasis and involve several enzymes including HMG-CoA reductase and squalene synthase. The cholesterol biosynthesis pathway includes multiple steps where FPP serves as a lipid intermediate. Meanwhile in protein prenylation FPP contributes to the post-translational modification of proteins such as small GTPases which impacts cell signaling and cytoskeletal organization.

FDPS has a connection to bone diseases such as osteoporosis and also links to cardiovascular disorders. The relationship to osteoporosis arises from its role in bone resorption and osteoclast activity mediated by proteins like RANKL and osteoprotegerin. Cardiovascular disorders may link to altered cholesterol metabolism with FDPS influencing cholesterol biosynthesis and regulation. Inhibition of FDPS activity targets these pathways leading to therapeutic strategies that may address both metabolic and bone health issues.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.

See full target information FDPS

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Publications (10)

Recent publications for all applications. Explore the full list and refine your search

Nature aging 5:2022-2038 PubMed40858817

2025

Mevalonate metabolites boost aged oocyte quality through prenylation of small GTPases.

Applications

Unspecified application

Species

Unspecified reactive species

Chuanming Liu,Huidan Zhang,Jialian Mao,Sainan Zhang,Xiao Tian,Yibing Zhu,Changjiang Wang,Junshun Fang,Huijie Pan,Nannan Kang,Yang Zhang,Jidong Zhou,Xin Zhen,Guijun Yan,Chaojun Li,Yali Hu,Cunqi Ye,Ran Xie,Chun So,Haixiang Sun,Lijun Ding

Diabetes, metabolic syndrome and obesity : targets and therapy 18:583-599 PubMed40026899

2025

Proteomic Analysis of the Effects of Shenzhu Tiaopi Granules on Model Rats with Type 2 Diabetes Mellitus.

Applications

Unspecified application

Species

Unspecified reactive species

Jin-Dong Zhao,Zhao-Hui Fang

Experimental and therapeutic medicine 28:361 PubMed39071912

2024

Sodium sulphate ameliorates hypercholesterolemia via the upregulation of in hepatocytes and alleviates hepatic insulin resistance via the downregulation of in mice with high cholesterol diets.

Applications

Unspecified application

Species

Unspecified reactive species

Yanhong Yang,Siping Yu,Hedong Rong,Zili Lei,Changyuan Yang,Huijuan Wu,Tianle Zhang,Fei Yang,Ya Nie,Lei Chen,Qing Hu,Qi Song,Jiao Guo

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 37:e23035 PubMed37310396

2023

Farnesyl diphosphate synthase exacerbates nonalcoholic steatohepatitis via the activation of AHR-CD36 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Jun Liu,Xinxin Zhang,Yufei Zhang,Minyi Qian,Maohui Yang,Song Yang,Lirui Wang

Frontiers in pharmacology 13:899469 PubMed35721132

2022

Zoledronic Acid Targeting of the Mevalonate Pathway Causes Reduced Cell Recruitment and Attenuates Pulmonary Fibrosis.

Applications

Unspecified application

Species

Unspecified reactive species

Lloyd Tanner,Jesper Bergwik,Andrew B Single,Ravi K V Bhongir,Jonas S Erjefält,Arne Egesten

eLife 10: PubMed33942715

2021

Qki regulates myelinogenesis through Srebp2-dependent cholesterol biosynthesis.

Applications

Unspecified application

Species

Unspecified reactive species

Xin Zhou,Seula Shin,Chenxi He,Qiang Zhang,Matthew N Rasband,Jiangong Ren,Congxin Dai,Rocío I Zorrilla-Veloz,Takashi Shingu,Liang Yuan,Yunfei Wang,Yiwen Chen,Fei Lan,Jian Hu

Translational psychiatry 10:3 PubMed32066669

2020

Protein expression of prenyltransferase subunits in postmortem schizophrenia dorsolateral prefrontal cortex.

Applications

Unspecified application

Species

Unspecified reactive species

Anita L Pinner,Toni M Mueller,Khaled Alganem,Robert McCullumsmith,James H Meador-Woodruff

Cancers 11: PubMed31569395

2019

N6-Isopentenyladenosine Inhibits Colorectal Cancer and Improves Sensitivity to 5-Fluorouracil-Targeting FBXW7 Tumor Suppressor.

Applications

Unspecified application

Species

Unspecified reactive species

Donatella Fiore,Chiara Piscopo,Maria Chiara Proto,Michele Vasaturo,Fabrizio Dal Piaz,Bruno Marcello Fusco,Cristina Pagano,Chiara Laezza,Maurizio Bifulco,Patrizia Gazzerro

Experimental & molecular medicine 50:1-12 PubMed30333528

2018

Farnesyl diphosphate synthase is important for the maintenance of glioblastoma stemness.

Applications

Unspecified application

Species

Unspecified reactive species

Hee Yeon Kim,Dong Keon Kim,Seung-Hyun Bae,HyeRan Gwak,Ji Hoon Jeon,Jong Kwang Kim,Byung Il Lee,Hye Jin You,Dong Hoon Shin,Young-Ho Kim,Soo Youl Kim,Sung-Sik Han,Jin-Kyoung Shim,Ji-Hyun Lee,Seok-Gu Kang,Hyonchol Jang

International journal of molecular medicine 35:1767-72 PubMed25847782

2015

Inhibition of farnesyl pyrophosphate synthase attenuates angiotensin II-induced fibrotic responses in vascular smooth muscle cells.

Applications

Unspecified application

Species

Unspecified reactive species

Chang-Qing Du,Xiao-Wei Liu,Guang-Zhong Zeng,Hong-Feng Jin,Li-Jiang Tang

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

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Anti-FDPS/FPS antibody

Western blot - Anti-FDPS/FPS antibody (AB153805)

Western blot - Anti-FDPS/FPS antibody (AB153805)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (10)

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