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AB316954

Anti-FENS1/WDFY1 antibody

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Rabbit Polyclonal WDFY1 antibody. Suitable for WB and reacts with Human, Mouse samples. Immunogen corresponding to Recombinant Fragment Protein within Human WDFY1.

View Alternative Names

FENS1, KIAA1435, WDF1, ZFYVE17, WDFY1, WD repeat and FYVE domain-containing protein 1, FYVE domain-containing protein localized to endosomes 1, Phosphoinositide-binding protein 1, WD40- and FYVE domain-containing protein 1, Zinc finger FYVE domain-containing protein 17, FENS-1

1 Images
Western blot - Anti-FENS1/WDFY1 Antibody (AB316954)
  • WB

Supplier Data

Western blot - Anti-FENS1/WDFY1 Antibody (AB316954)

All lanes:

Western blot - Anti-FENS1/WDFY1 Antibody (ab316954) at 1/2000 dilution

Lane 1:

RAW 264.7 (Mouse macrophage cell line transformed with Abelson murine leukemia virus) whole cell lysate

Lane 2:

THP-1 (Human monocytic leukemia cell line) whole cell lysate

Lane 3:

Mouse brain tissue lysate

Lane 4:

Mouse liver tissue lysate

Lane 5:

Mouse kidney tissue lysate

Secondary

All lanes:

Goat polyclonal to rabbit IgG at 1/50000 dilution

Observed band size: 47 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human, Mouse

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human WDFY1.

Q8IWB7

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C|-80°C
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FENS1 also known as WDFY1 is a protein that plays a role in several cellular processes. It has a mass of approximately 80 kDa. The protein is predominantly expressed in several tissues including the brain heart and skeletal muscle. FENS1 is known for its involvement in cellular signaling and serves as a scaffolding protein interacting with other molecules to facilitate various cellular functions.
Biological function summary

FENS1/WDFY1 impacts immune system responses. It is part of a complex that includes other proteins suggesting its role in cellular defense mechanisms against pathogens. The protein aids in orchestrating the interactions between signaling molecules and receptors promoting effective communications within immune cells. Its involvement is critical for maintaining a balanced immune response and it affects both innate and adaptive immunity functions.

Pathways

FENS1/WDFY1 interacts with a few signaling pathways particularly the Toll-like receptor signaling. This pathway is essential for the recognition and response to microbial components. FENS1/WDFY1 collaborates with related proteins such as MyD88 to ensure proper signal transduction which is necessary for activating immune responses. Another pathway related to FENS1/WDFY1 includes NF-kB signaling which is important for immune regulation and inflammation processes.

FENS1/WDFY1 has associations with immune-related conditions such as autoimmune disorders and inflammatory diseases. The dysfunction or altered expression of FENS1/WDFY1 can disrupt normal immune signaling leading to conditions like rheumatoid arthritis. Moreover relations between FENS1/WDFY1 and other proteins like TLR4 emphasize its potential role in modulating inflammatory responses seen in these diseases. Understanding these connections can provide insights into therapeutic targets for better managing these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1. Promotes TLR3/4 ligand-induced activation of transcription factors IRF3 and NF-kappa-B, as well as the production of IFN-beta and inflammatory cytokines (PubMed : 25736436).
See full target information WDFY1
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Product promise

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