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Rabbit Recombinant Monoclonal FES antibody. Suitable for WB, ICC/IF, Flow Cyt (Intra) and reacts with Human samples.

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Images

Western blot - Anti-FES antibody [EPR3230(2)] (AB108418), expandable thumbnail
  • Flow Cytometry (Intracellular) - Anti-FES antibody [EPR3230(2)] (AB108418), expandable thumbnail
  • Immunocytochemistry/ Immunofluorescence - Anti-FES antibody [EPR3230(2)] (AB108418), expandable thumbnail

Key facts

Isotype
IgG
Host species
Rabbit
Storage buffer

pH: 7.2 - 7.4
Preservative: 0.01% Sodium azide
Constituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9% PBS, 0.05% BSA

Form
Liquid
Clonality
Monoclonal

Immunogen

  • The exact immunogen used to generate this antibody is proprietary information.

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WBIHC-PICC/IFFlow Cyt (Intra)
Human
Tested
Not recommended
Tested
Tested

Tested
Tested

Species
Human
Dilution info
1/1000 - 1/10000
Notes

-

Not recommended
Not recommended

Species
Human
Dilution info
-
Notes

-

Tested
Tested

Species
Human
Dilution info
1/100 - 1/250
Notes

-

Tested
Tested

Species
Human
Dilution info
1/100
Notes

-

Associated Products

Select an associated product type

1 product for Alternative Product

Target data

Function

Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28.

Alternative names

FPS, FES, Tyrosine-protein kinase Fes/Fps, Feline sarcoma/Fujinami avian sarcoma oncogene homolog, Proto-oncogene c-Fes, Proto-oncogene c-Fps, p93c-fes

Recommended products

Rabbit Recombinant Monoclonal FES antibody. Suitable for WB, ICC/IF, Flow Cyt (Intra) and reacts with Human samples.

Key facts

Isotype
IgG
Form
Liquid
Clonality
Monoclonal
Immunogen
  • The exact immunogen used to generate this antibody is proprietary information.
Clone number
EPR3230(2)
Purity
Tissue culture supernatant
Concentration
Loading...

Storage

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Stable for 12 months at -20°C

Notes

Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.
Activity summary

The FES protein also known as Feline Sarcoma Oncogene is a cytoplasmic tyrosine kinase with a molecular mass of approximately 93 kDa. It plays a role in regulating processes like cell growth differentiation and survival. FES is mainly expressed in hematopoietic cells endothelial cells and some neural tissues. Its structure includes SH2 and SH3 domains allowing the protein to interact with other cellular components.

Biological function summary

FES protein is involved in signal transduction pathways that control various physiological functions. It does not form part of any giant complexes rather it serves as a relay point for signals in cellular contexts. The kinase activity of FES is important for ensuring cellular processes such as actin remodeling an important process for cell movement and shape changes.

Pathways

The FES protein participates in the RAS and MAPK signaling pathways. These pathways are important for transmitting extracellular signals that govern cell fate decisions. FES interacts with proteins such as GRB2 and SOS1 in these pathways to modulate downstream effects and enable effective response to cellular stimuli.

Associated diseases and disorders

Aberrant FES signaling has links to cancer and inflammatory disorders. Dysregulation of FES can contribute to several types of cancer including leukemia due to its effect on cell proliferation and survival. In inflammation FES interaction with proteins like STAT3 may promote pathological inflammatory responses therefore implicating FES in diseases such as rheumatoid arthritis.

Product promise

We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

3 product images

  • Western blot - Anti-FES antibody [EPR3230(2)] (ab108418), expandable thumbnail

    Western blot - Anti-FES antibody [EPR3230(2)] (ab108418)

    All lanes: Western blot - Anti-FES antibody [EPR3230(2)] (ab108418) at 1/1000 dilution

    Lane 1: TF-1 lysate at 10 µg

    Lane 2: U937 lysate at 10 µg

    Lane 3: Human spleen lysate at 10 µg

    Predicted band size: 93 kDa

  • Flow Cytometry (Intracellular) - Anti-FES antibody [EPR3230(2)] (ab108418), expandable thumbnail

    Flow Cytometry (Intracellular) - Anti-FES antibody [EPR3230(2)] (ab108418)

    Flow Cytometry analysis of HeLa (Human cervix adenocarcinoma epithelial cell) cells labeling FES with purified ab108418 at 1/100 dilution (10 µg/mL) (Red). Cells were fixed with 4% Paraformaldehyde and permeabilised with 90% Methanol. A Goat anti rabbit IgG (Alexa Fluor® 488, Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) ab150077) secondary antibody was used at 1/2000. Isotype control - Rabbit monoclonal IgG (Black). Unlabeled control - Cells without incubation with primary antibody and secondary antibody (Blue).

  • Immunocytochemistry/ Immunofluorescence - Anti-FES antibody [EPR3230(2)] (ab108418), expandable thumbnail

    Immunocytochemistry/ Immunofluorescence - Anti-FES antibody [EPR3230(2)] (ab108418)

    ab108418, at a 1/100 dilution, staining FES in HeLa (Human epithelial cell line from cervix adenocarcinoma) cells by Immunofluorescence.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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