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AB19363

Anti-Fetal Hemoglobin antibody

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(1 Publication)

Sheep Polyclonal HBG1 antibody. Suitable for Ie, DID and reacts with Human samples. Cited in 1 publication.

View Alternative Names

A gamma globin, G gamma globin, Gamma 1 globin, Gamma 2 globin, Gamma A hemoglobin, Gamma globin, HBGA, HBGR, HSGGL 1, Hb F Agamma, Hb F Ggamma, Hemoglobin gamma 1 chain, Hemoglobin gamma 2 chain, Hemoglobin gamma A, Hemoglobin gamma A chain, Hemoglobin gamma G, Hemoglobin gamma G chain, Hemoglobin gamma regulator of, Hemoglobin subunit gamma 1, Hemoglobin subunit gamma 2, Methemoglobin, PRO 2979

Key facts

Host species

Sheep

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

DID, Ie

applications

Specificity

By immunoelectrophoresis, the antiserum reacts specifically with human fetal hemoglobin. No antibody was detected against hemoglobin A1, A2, S or human serum proteins.

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AB108414

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Band 3/AE 1 antibody [EPR1426] (AB108414)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "Ie" : {"fullname" : "Immunoelectrophoresis", "shortname":"Ie"}, "DID" : {"fullname" : "Double Immunodiffusion", "shortname":"DID"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "Ie-species-checked": "guaranteed", "Ie-species-dilution-info": "", "Ie-species-notes": "<p></p>", "DID-species-checked": "guaranteed", "DID-species-dilution-info": "", "DID-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purity
IgG fraction
Purification notes
Antiserum was solid phase adsorbed against hemoglobin A to ensure specificity. The antiserum was fractionated and passed over DEAE to yield an IgG fraction.
Storage buffer
pH: 6.8 - 7.4 Preservative: 0.1% Sodium azide Constituents: 1.21% Tris, 0.02% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Fetal hemoglobin also known as fetal Hb or HbF is a form of hemoglobin found in fetuses and neonates. HbF is composed of two alpha and two gamma globin chains and its molecular weight is around 64000 Daltons. This hemoglobin variant is mainly expressed in the red blood cells of the fetal liver and bone marrow. Expression of fetal hemoglobin typically declines after birth when beta globin chains replace gamma chains to form adult hemoglobin (HbA). However low levels of fetal hemoglobin can persist into adulthood in some individuals.
Biological function summary

Fetal hemoglobin has a higher affinity for oxygen compared to adult hemoglobin. This characteristic allows efficient transfer of oxygen from maternal to fetal circulation which is vital for fetal development. Fetal hemoglobin is not part of any complex but its unique structure is adapted to its function in the fetal environment. The alpha and gamma globin chains together modulate its oxygen-binding properties ensuring proper oxygenation during fetal life.

Pathways

The production and transition of fetal hemoglobin are linked to the globin gene switching pathway. This process involves the silencing of gamma globin genes and activation of beta globin genes postnatally a transition integral to producing adult hemoglobin. BCL11A and KLF1 are transcription factors that play essential roles in regulating this gene switching. Both proteins influence the repression of gamma globin genes therefore promoting the expression of beta globin.

Fetal hemoglobin is significant in conditions like sickle cell disease and beta thalassemia. In these disorders elevated levels of fetal hemoglobin can ameliorate symptoms by compensating for defective adult hemoglobin. Patients with higher fetal hemoglobin levels typically exhibit milder forms of these diseases. Therapeutic approaches aim to reactivate fetal hemoglobin expression through the modulation of proteins like BCL11A KLF1 and others involved in hemoglobin switching.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Fetal hemoglobin
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 14:8272 PubMed38594253

2024

Identification of small molecules affecting the interaction between human hemoglobin and Staphylococcus aureus IsdB hemophore.

Applications

Unspecified application

Species

Unspecified reactive species

Monica Cozzi,Mariacristina Failla,Eleonora Gianquinto,Sandra Kovachka,Valeria Buoli Comani,Carlotta Compari,Omar De Bei,Roberta Giaccari,Francesco Marchesani,Marialaura Marchetti,Luca Ronda,Barbara Rolando,Massimo Baroni,Gabriele Cruciani,Barbara Campanini,Stefano Bettati,Serena Faggiano,Loretta Lazzarato,Francesca Spyrakis
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Product promise

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