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AB227302

Anti-FGD1 antibody - C-terminal

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(1 Publication)

Rabbit Polyclonal FGD1 antibody. C-terminal. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human FGD1.

View Alternative Names

FGDY, ZFYVE3, FGD1, Faciogenital dysplasia 1 protein, Rho/Rac guanine nucleotide exchange factor FGD1, Zinc finger FYVE domain-containing protein 3, Rho/Rac GEF

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human FGD1. The exact immunogen used to generate this antibody is proprietary information.

P98174

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The FGD1 protein also known as faciogenital dysplasia protein is a member of the Rho guanine nucleotide exchange factor family and has a molecular weight of approximately 63 kDa. It participates in the act of activating the Rho GTPase Cdc42 which regulates cytoskeletal dynamics in cells. FGD1 mainly expresses in fetal and adult tissues such as heart brain and testis suggesting its significance in various developmental and functional roles within these areas.
Biological function summary

The FGD1 protein functions as an essential modulator of cell morphology motility and intracellular signaling pathways. It plays a part in a larger complex that influences actin cytoskeleton rearrangement and transcriptional activity. Through its interaction with other proteins FGD1 facilitates processes such as cell division migration and development indicating its broad impact on cellular activities.

Pathways

The FGD1 protein intricately fits into signaling mechanisms like the Rho GTPase signaling pathway and the Wnt signaling pathway. Within the Rho GTPase pathway FGD1 works closely with proteins like Cdc42 to regulate cytoskeletal reorganization and membrane trafficking. Additionally its engagement in the Wnt signaling pathway influences various developmental processes exhibiting its versatility in cellular communication and responses.

FGD1 holds notable relevance with disorders such as Aarskog-Scott syndrome and possibly involves other diseases related to craniofacial and skeletal development. The disruption in FGD1 function associates with anomalies linked to Aarskog-Scott syndrome where it interacts with proteins such as filamin A. These associations highlight the importance of FGD1 in maintaining proper developmental and structural functions within the body.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape.
See full target information FGD1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Diabetes, metabolic syndrome and obesity : targets and therapy 18:217-231 PubMed39896707

2025

PEDF Overexpression Ameliorates Cardiac Lipotoxicity in Diabetic Cardiomyopathy via Regulation of Energy Metabolism.

Applications

Unspecified application

Species

Unspecified reactive species

Tuohua Mao,Ye Wang
View all publications
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