AB229630

Anti-FGF-15 antibody

Name: Anti-FGF-15 antibody. Rabbit polyclonal (ab229630) | Abcam
Brand: Abcam Limited
SKU: AB229630
Price: 420 USD
Availability: InStock

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(17 Publications)

Rabbit Polyclonal FGF-15 antibody. Suitable for WB and reacts with Mouse samples. Cited in 17 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Mouse Fgf15.

View Alternative Names

Fibroblast growth factor 15, FGF-15, Fgf15

1 Images

Supplier Data

Western blot - Anti-FGF-15 antibody (AB229630)

All lanes:

Western blot - Anti-FGF-15 antibody (ab229630) at 1/1000 dilution

Lane 1:

Mouse Liver tissue lysate

Lane 2:

Mouse Spleen tissue lysate

Lane 3:

Mouse Lung tissue lysate

Secondary

All lanes:

Goat polyclonal to rabbit IgG at 1/50000 dilution

Observed band size: 26 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse

Applications

applications

Immunogen

Recombinant Full Length Protein corresponding to Mouse Fgf15.

O35622

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein G

Purification notes

Purity >95%.

Storage buffer

pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FGF-15 also known as fibroblast growth factor 15 is a protein with a significant role in various physiological processes. This protein belongs to the fibroblast growth factor (FGF) family and has a molecular mass of approximately 25 kDa. FGF-15 is predominantly expressed in the intestines particularly in the ileum. Its main mechanical function involves the modulation of bile acid synthesis which occurs through its actions on specific receptor targets.

Biological function summary

FGF-15 plays a critical role in liver function and metabolism. It acts as a regulatory factor in bile acid homeostasis and glucose metabolism ensuring the balance and maintenance within the body. FGF-15 does not primarily function as part of a protein complex but it exerts its influence by binding to the fibroblast growth factor receptor 4 (FGFR4) associated with the β-Klotho co-receptor eliciting a signaling cascade important for maintaining metabolic homeostasis.

Pathways

FGF-15 engages in the enterohepatic circulation of bile acids and has a pivotal role in the suppression of bile acid synthesis. One of the key pathways involves fibroblast growth factor receptor signaling pathway. In this capacity FGF-15 works in conjunction with proteins such as FGFR4 and β-Klotho forming a signaling axis that influences the expression of cytochrome P450 family 7 subfamily A member 1 (CYP7A1) an important enzyme in bile acid biosynthesis.

FGF-15 is closely associated with metabolic conditions particularly liver diseases such as non-alcoholic fatty liver disease (NAFLD). Elevated levels of protein expression or dysregulation of its pathway may contribute to the development or progression of such disorders. Additionally abnormalities in the FGF-15 signaling can also impact glucose homeostasis linking it to diabetes. In these contexts FGF-15 works closely with FGFR4 and β-Klotho both important in the therapeutic targeting of these metabolic diseases.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
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Target data

Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression.

See full target information Fgf15

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Publications (17)

Recent publications for all applications. Explore the full list and refine your search

Chinese medicine 20:68 PubMed40414923

2025

ZeXieYin formula alleviates atherosclerosis by regulating SBAs levels through the FXR/FGF15 pathway and restoring intestinal barrier integrity.

Applications

Unspecified application

Species

Unspecified reactive species

Shihan Zhou,Shangbo Hua,Xinyi Chen,Meiling Ni,Jing Liu,Yanqing Wang,Wanning Wu,Anni Ding,Zizhen Qin,Xinyu Yang,Xiaowei Chen,Boran Zhu,Haoxin Wu

Journal of inflammation research 18:3161-3176 PubMed40065908

2025

Alleviates Colitis by Regulating FXR-NLRP3 Mediated Macrophage Pyroptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Lijiao Yang,Wanyu Li,Qianjing Zhao,Qi Mo,Tianyu Liu,Hailong Cao

iScience 26:108392 PubMed38025767

2023

relieves intrahepatic cholestasis of pregnancy through bile acid/FXR-FGF15 in rats.

Applications

Unspecified application

Species

Unspecified reactive species

Hanxiang Sun,Xiujuan Su,Yang Liu,Guohua Li,Qiaoling Du

Mediators of inflammation 2023:4188510 PubMed37780399

2023

Trans-Anethole Alleviates DSS-Induced Ulcerative Colitis by Remodeling the Intestinal Flora to Regulate Immunity and Bile Acid Metabolism.

Applications

Unspecified application

Species

Unspecified reactive species

Xu-Hui Li,Li Liu,Wen-Zhong Wu

Frontiers in pharmacology 14:1148737 PubMed37077819

2023

Geniposide plus chlorogenic acid reverses non-alcoholic steatohepatitis regulation of gut microbiota and bile acid signaling in a mouse model .

Applications

Unspecified application

Species

Unspecified reactive species

Hongshan Li,Yingfei Xi,Xin Xin,Qin Feng,Yiyang Hu

Nutrition & metabolism 19:76 PubMed36348361

2022

Curcumin improves insulin sensitivity in high-fat diet-fed mice through gut microbiota.

Applications

Unspecified application

Species

Unspecified reactive species

Yue Zhong,Yang Xiao,Jing Gao,Zhaozheng Zheng,Ziheng Zhang,Lu Yao,Dongmin Li

Journal of the science of food and agriculture 103:1283-1293 PubMed36087337

2022

L-Theanine regulates lipid metabolism by modulating gut microbiota and bile acid metabolism.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Xu,Yingying Kong,Tuo Zhang,Zhihua Gong,Wenjun Xiao

Cancer cell international 22:248 PubMed35945579

2022

STAT3-mediated upregulation of LINC00520 contributed to temozolomide chemoresistance in glioblastoma by interacting with RNA-binding protein LIN28B.

Applications

Unspecified application

Species

Unspecified reactive species

Shuai Yuan,Qi Yan,Zhi-Yong Zhao,Jing-Long Zhang,He Zhang,Hang Yin,Zhi Yuan

Frontiers in nutrition 9:914323 PubMed35845769

2022

SYF-08 Protects Against Pb-Induced Injury in Young Mice by Regulating Bile Acid Metabolism and Increasing Pb Excretion.

Applications

Unspecified application

Species

Unspecified reactive species

Zhenhui Chen,Ziyu Tang,Jingjing Kong,Lixuan Chen,Jiaxin Liu,Yunting Li,Wanwen Huang,Wendan Li,Junlin Wu,Wei Zhao,Xiaojing Meng,Hongying Fan

mSystems 7:e0017222 PubMed35670534

2022

Dietary Exposure to Antibiotic Residues Facilitates Metabolic Disorder by Altering the Gut Microbiota and Bile Acid Composition.

Applications

Unspecified application

Species

Unspecified reactive species

Rou-An Chen,Wei-Kai Wu,Suraphan Panyod,Po-Yu Liu,Hsiao-Li Chuang,Yi-Hsun Chen,Qiang Lyu,Hsiu-Ching Hsu,Tzu-Lung Lin,Ting-Chin David Shen,Yu-Tang Yang,Hsin-Bai Zou,Huai-Syuan Huang,Yu-En Lin,Chieh-Chang Chen,Chi-Tang Ho,Hsin-Chih Lai,Ming-Shiang Wu,Cheng-Chih Hsu,Lee-Yan Sheen

View all publications

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Product promise

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Anti-FGF-15 antibody

Western blot - Anti-FGF-15 antibody (AB229630)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (17)

Complementary Products

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

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