Rabbit Polyclonal FGF-15 antibody. Suitable for WB and reacts with Mouse samples. Cited in 14 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Mouse Fgf15.
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- iScience 26:1083922023relieves intrahepatic cholestasis of pregnancy through bile acid/FXR-FGF15 in rats.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHanxiang Sun,Xiujuan Su,Yang Liu,Guohua Li,Qiaoling DuPubMed 38025767
- Mediators of inflammation 2023:41885102023Trans-Anethole Alleviates DSS-Induced Ulcerative Colitis by Remodeling the Intestinal Flora to Regulate Immunity and Bile Acid Metabolism.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXu-Hui Li,Li Liu,Wen-Zhong WuPubMed 37780399
- Frontiers in pharmacology 14:11487372023Geniposide plus chlorogenic acid reverses non-alcoholic steatohepatitis regulation of gut microbiota and bile acid signaling in a mouse model .Applications:Unspecified applicationReactive species:Unspecified reactive speciesHongshan Li,Yingfei Xi,Xin Xin,Qin Feng,Yiyang HuPubMed 37077819
- Nutrition & metabolism 19:762022Curcumin improves insulin sensitivity in high-fat diet-fed mice through gut microbiota.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYue Zhong,Yang Xiao,Jing Gao,Zhaozheng Zheng,Ziheng Zhang,Lu Yao,Dongmin LiPubMed 36348361
- Journal of the science of food and agriculture 103:1283-12932022L-Theanine regulates lipid metabolism by modulating gut microbiota and bile acid metabolism.Applications:Unspecified applicationReactive species:Unspecified reactive speciesWei Xu,Yingying Kong,Tuo Zhang,Zhihua Gong,Wenjun XiaoPubMed 36087337
- Frontiers in nutrition 9:9143232022SYF-08 Protects Against Pb-Induced Injury in Young Mice by Regulating Bile Acid Metabolism and Increasing Pb Excretion.Applications:Unspecified applicationReactive species:Unspecified reactive speciesZhenhui Chen,Ziyu Tang,Jingjing Kong,Lixuan Chen,Jiaxin Liu,Yunting Li,Wanwen Huang,Wendan Li,Junlin Wu,Wei Zhao,Xiaojing Meng,Hongying FanPubMed 35845769
- mSystems 7:e00172222022Dietary Exposure to Antibiotic Residues Facilitates Metabolic Disorder by Altering the Gut Microbiota and Bile Acid Composition.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRou-An Chen,Wei-Kai Wu,Suraphan Panyod,Po-Yu Liu,Hsiao-Li Chuang,Yi-Hsun Chen,Qiang Lyu,Hsiu-Ching Hsu,Tzu-Lung Lin,Ting-Chin David Shen,Yu-Tang Yang,Hsin-Bai Zou,Huai-Syuan Huang,Yu-En Lin,Chieh-Chang Chen,Chi-Tang Ho,Hsin-Chih Lai,Ming-Shiang Wu,Cheng-Chih Hsu,Lee-Yan SheenPubMed 35670534
- Biochimica et biophysica acta. Molecular basis of disease 1868:1663202021Prevotella copri ameliorates cholestasis and liver fibrosis in primary sclerosing cholangitis by enhancing the FXR signalling pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesBaorong Jiang,Gehui Yuan,Jialin Wu,Qian Wu,Lei Li,Ping JiangPubMed 34896545
- American journal of translational research 13:9296-93052021Effect of Glycyrrhiza uralensis against ulcerative colitis through regulating the signaling pathway of FXR/P-gp.Applications:Unspecified applicationReactive species:Unspecified reactive speciesQin Lu,Xiaoqian Wu,Wei Han,Wei Zhang,Yi Wang,Desong Kong,Zhimin FanPubMed 34540046
- Frontiers in pharmacology 12:7010032021Polysaccharides Ameliorate Diet-Induced Gallstone Formation by Modulating Synthesis of Bile Acids and the Gut Microbiota.Applications:Unspecified applicationReactive species:Unspecified reactive speciesQian Zhuang,Xin Ye,Shuang Shen,Jinnian Cheng,Yan Shi,Shan Wu,Jie Xia,Min Ning,Zhixia Dong,Xinjian WanPubMed 34276384
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.03% Proclin 300
Constituents: PBS, 50% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Full Length Protein corresponding to Mouse Fgf15. Database link O35622
Reactivity data
Select an application| WB | |
|---|---|
| Mouse | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 1/500 - 1/5000 | Notes - |
Target data
Function
Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression.
Alternative names
Fibroblast growth factor 15, FGF-15, Fgf15
Recommended products
Rabbit Polyclonal FGF-15 antibody. Suitable for WB and reacts with Mouse samples. Cited in 14 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Mouse Fgf15.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.03% Proclin 300
Constituents: PBS, 50% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Full Length Protein corresponding to Mouse Fgf15. Database link O35622
- Purification technique
- Affinity purification Protein G
- Concentration
- Purification notes
Purity >95%.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
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Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
FGF-15 also known as fibroblast growth factor 15 is a protein with a significant role in various physiological processes. This protein belongs to the fibroblast growth factor (FGF) family and has a molecular mass of approximately 25 kDa. FGF-15 is predominantly expressed in the intestines particularly in the ileum. Its main mechanical function involves the modulation of bile acid synthesis which occurs through its actions on specific receptor targets.
- Biological function summary
FGF-15 plays a critical role in liver function and metabolism. It acts as a regulatory factor in bile acid homeostasis and glucose metabolism ensuring the balance and maintenance within the body. FGF-15 does not primarily function as part of a protein complex but it exerts its influence by binding to the fibroblast growth factor receptor 4 (FGFR4) associated with the β-Klotho co-receptor eliciting a signaling cascade important for maintaining metabolic homeostasis.
- Pathways
FGF-15 engages in the enterohepatic circulation of bile acids and has a pivotal role in the suppression of bile acid synthesis. One of the key pathways involves fibroblast growth factor receptor signaling pathway. In this capacity FGF-15 works in conjunction with proteins such as FGFR4 and β-Klotho forming a signaling axis that influences the expression of cytochrome P450 family 7 subfamily A member 1 (CYP7A1) an important enzyme in bile acid biosynthesis.
- Associated diseases and disorders
FGF-15 is closely associated with metabolic conditions particularly liver diseases such as non-alcoholic fatty liver disease (NAFLD). Elevated levels of protein expression or dysregulation of its pathway may contribute to the development or progression of such disorders. Additionally abnormalities in the FGF-15 signaling can also impact glucose homeostasis linking it to diabetes. In these contexts FGF-15 works closely with FGFR4 and β-Klotho both important in the therapeutic targeting of these metabolic diseases.
Product promise
Tested
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Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Western blot - Anti-FGF-15 antibody (ab229630)
All lanes: Western blot - Anti-FGF-15 antibody (ab229630) at 1/1000 dilution
Lane 1: Mouse Liver tissue lysate
Lane 2: Mouse Spleen tissue lysate
Lane 3: Mouse Lung tissue lysate
SecondaryAll lanes: Goat polyclonal to rabbit IgG at 1/50000 dilution
Observed band size: 26 kDa
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