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AB123502

Anti-FGF 23 antibody

0

(1 Review)

|

(2 Publications)

Goat Polyclonal fibroblast growth factor 23 precursor antibody. Suitable for WB and reacts with Mouse samples. Cited in 2 publications.
2 Images
Western blot - Anti-FGF 23 antibody (AB123502)
  • WB

Unknown

Western blot - Anti-FGF 23 antibody (AB123502)

Primary incubation was 1 hour. Detected by chemiluminescence.

All lanes:

Western blot - Anti-FGF 23 antibody (ab123502) at 0.5 µg/mL

All lanes:

Mouse brain lysate in RIPA buffer at 35 µg

Predicted band size: 28 kDa

Observed band size: 27 kDa,38 kDa

false

Western blot - Anti-FGF 23 antibody (AB123502)
  • WB

Supplier Data

Western blot - Anti-FGF 23 antibody (AB123502)

All lanes:

Western blot - Anti-FGF 23 antibody (ab123502)

Lane 1:

Mouse Testes Lysate 1 in RIPA buffer at 35 µg

Lane 2:

Mouse Testes Lysate 2 in RIPA buffer at 35 µg

Lane 3:

Mouse Testes Lysate in RIPA buffer with blocking peptide at 35 µg

Predicted band size: 28 kDa

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Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

WB

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.3-1 µg/mL", "WB-species-notes": "<p>A 1 hour primary incubation is recommended for this product. When using mouse brain lysate:</p>" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: 99% Tris buffered saline, 0.5% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Fibroblast Growth Factor 23 also known as FGF 23 is a hormone-like protein that plays a role in phosphate and vitamin D metabolism. It is a member of the fibroblast growth factor family and consists of about 251 amino acids with a mass of approximately 32 kDa. FGF 23 is predominantly expressed in bone cells especially osteocytes but it also appears in other tissues such as the thymus and brain. An important tool for quantitative measurement of FGF 23 levels is the FGF 23 ELISA kit which assists in various research and clinical settings.
Biological function summary

FGF 23 plays an important role in regulating phosphate balance in the body. It impacts the function of kidneys by decreasing the reabsorption of phosphate and suppressing the formation of active vitamin D thereby affecting calcium regulation as well. FGF 23 does not operate alone but interacts with co-receptors such as Klotho to activate its receptor complex. The protein functions as part of a larger system that fine-tunes the balance of minerals important for maintaining bone health and metabolic functions.

Pathways

FGF 23 is part of the bone-mineral metabolism axis and is integral to the phosphate regulation pathway. It works closely with proteins like Klotho and FGFR1 and their interaction ensures proper signaling required for maintaining serum phosphate levels. FGF 23 controls vitamin D metabolism by regulating the expression of 1-alpha-hydroxylase and 24-hydroxylase influencing the activity of the related vitamin D endocrine system. Its actions help stabilize phosphate and vitamin D status which are both essential for skeletal and mineral homeostasis.

FGF 23 has a significant connection to conditions such as Hypophosphatemic Rickets and Chronic Kidney Disease (CKD). In these cases FGF 23 levels may become dysregulated leading to abnormal phosphate metabolism and bone mineralization defects. In Hypophosphatemic Rickets altered expression of FGF 23 causes excessive phosphate wasting whereas in CKD increased FGF 23 levels are associated with cardiovascular disease risk and deteriorating kidney function. Klotho as a coreceptor for FGF 23 also influences these pathological conditions highlighting its contribution to phosphate-related disorder mechanisms.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information fibroblast growth factor 23 precursor
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 13:8856 PubMed37258605

2023

Next-generation RNA sequencing elucidates transcriptomic signatures of pathophysiologic nerve regeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Wesley S Warner,Christopher Stubben,Stewart Yeoh,Alan R Light,Mark A Mahan

Frontiers in cardiovascular medicine 10:990422 PubMed36895836

2023

Indoxyl sulfate induces left ventricular hypertrophy the AhR-FGF23-FGFR4 signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Hiroshi Kishimoto,Toshiaki Nakano,Kumiko Torisu,Masanori Tokumoto,Yushi Uchida,Shunsuke Yamada,Masatomo Taniguchi,Takanari Kitazono
View all publications
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Complementary Products

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Product promise

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